Howard & Jan Oringer Seminar

Computational biology is playing important roles in precision cancer therapy.  I will discuss our efforts using computational biology to mine high throughput sequencing data in order to aid translational cancer research.  Specifically I will discuss three areas of our current foci: using public ChIP-seq data to understand cancer gene regulation, using CRISPR screen data to identify tumor vulnerabilities and targeted combination therapy, and using RNA-seq data to model tumor infiltrating Xiaole Shirleyimmune cells and T-cell repertoires.