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W. N. Lacey Lectureship in Chemical Engineering

Wednesday, February 20, 2019
4:00pm to 5:00pm
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Spalding Laboratory 106 (Hartley Memorial Seminar Room)
Tools of the Trade: Influencing the Cellular Microenvironment In Vitro and In Vivo (Technical Lecture)
Molly Shoichet, University Professor and Canada Research Chair, Tissue Engineering Senior Advisor to President on Science & Engineering Engagement , Chemical Engineering & Applied Chemistry, University of Toronto,

The cellular microenvironment influences cell fate both in vitro and in vivo.  For the former, we are interested in screening cells in an environment that mimics that of native tissue, and to this end, we designed a hydrogel for 3D cell culture. With 3D cell culture, we gain an understanding of both cell invasion and cell viability, thereby providing insight that is inherently unavailable with traditional 2D cell culture.  To achieve a suitable environment, we synthesized hyaluronan-based hydrogels because hyaluronan is often over-expressed in invasive tumours including those in the breast and lung.  With precise control of the crosslinking chemistry, we influence the physical and mechanical properties, enabling us to investigate both breast and lung cancer cell invasion and their responses to different therapeutic treatments.  For the latter, we are interested in stimulating the host tissue to achieve repair. Here, we have created novel strategies for protein delivery based on affinity and electrostatic interactions and have tested these strategies in animal models of spinal cord injury and stroke.

For more information, please contact Sohee Lee by phone at 626-395-4193 or by email at [email protected].