Thomas Miller - Signed, Sealed, Delivered: How Proteins Get Where They're Supposed to Go in Cells

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Although proteins are only synthesized in specialized cellular locations, they are destined for delivery to all corners of the cell, and beyond. A key step in this delivery process is the efficient transport, or translocation, of the newly synthesized proteins across cell membranes. Protein translocation involves a delicate balance between processes that range from atomistic interactions to macromolecular rearrangements.

Recent structural studies offer high-resolution glimpses into the translocation process, but many fundamental aspects of its mechanism and regulation remain poorly understood.  Dr. Miller's research group is developing methods to computationally simulate the protein translocation process and to predict ways to control the targeting and delivery of proteins for therapeutic or biotechnological applications.

Thomas Miller is a professor of chemistry at Caltech.

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Presented by: Caltech Committee on Institute Programs