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Robert W. Vaughan Lecture in Chemical Engineering

Thursday, February 19, 2015
4:00pm to 5:00pm
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Spalding Laboratory 106 (Hartley Memorial Seminar Room)
Discovery and engineering new enzymes from nature
Yi Tang, Professor and Vice-Chair, Chemical and Biomolecular Engineering, University of California, Los Angeles,

Biosynthesis of structurally complex natural products requires the coordinated actions of many enzymes.  Through the discovery and characterization of natural product biosynthetic pathways, many enzymes of novel structures and functions have been identified.  In this talk, I will discuss some interesting examples from our recent work on both bacterial and fungal secondary metabolism.  We will highlight studies on well-known (such as tetracycline and lovastatin) and newly discovered natural products.  In addition, I will also present protein engineering efforts in which a biosynthetic enzyme was converted into a commercial biocatalyst for the semisynthesis of a blockbuster drug.

For more information, please contact Emily Loiacano by email at [email protected].