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Organic Chemistry Special Seminar

Friday, June 21, 2019
4:00pm to 5:00pm
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Noyes 147 (J. Holmes Sturdivant Lecture Hall)
Asymmetric Functionalization of C-H Bonds via Copper-Catalyzed Radical Relay
Guosheng Liu, Professor, State Key Laboratory of Organometallic Chemistry, Shanghai Institute of Organic Chemistry,

Due to the highly active radical intermediate, the organic transformation via radical pathway have been extensively studied. However, the selective control of radical intermediate is extremely challenging, which significantly retards the success of highly selective radical reaction, specially for the enantioselective version. Recently, Our group recently reveals that the stereoselective control of radical could be achieved by using copper catalyst, and a series of enantioselective difunctionalization of alkenes have been explored by using bisoxazoline (Box)/Cu(I) catalytic system. In these studies, a benzylic radical intermediate was involved in the catalytic cycles, which can be enantioselectively traped by (Box)/CuII intermediate to produce enantiomerically enriched products. In this talk, I'd like to introduced our recent progress in the asymmetric oxidative functionalization of C-H bonds, including benzylic and allylic C-H bonds, wherein copper catalyst plays important roles on the both site- and enantioselectivity.

For more information, please contact Annette Luymes by phone at 626-395-6016 or by email at [email protected].