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Organic Chemistry Seminar

Tuesday, February 17, 2015
4:00pm to 5:00pm
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Noyes 147 (J. Holmes Sturdivant Lecture Hall)
Metal Catalysis of Nontraditional Electrophiles
Mary P. Watson, Assistant Professor of Chemistry, Department of Chemistry and Biochemistry, University of Delaware,

I will present our research on the development of transition-metal catalyzed reactions employing non-traditional electrophiles. We have developed enantioselective, copper-catalyzed alkynylations of oxocarbenium ion intermediates, which enable efficient access to highly enantioenriched oxygen heterocycles with alpha stereogenic centers. We have also identified reaction conditions for enantiospecific, nickel-catalyzed cross couplings of amine- and alcohol-derived alkyl electrophiles. The optimization and scope of these transformations will be discussed, along with our mechanistic and stereochemical hypotheses and supporting experiments. 

For more information, please contact Lynne Martinez by phone at 626-395-4004 or by email at [email protected].