Organic Chemistry Seminar
We are pursuing to expand the scope of catalysis in organic synthesis as well as life science. Because "life is simply a matter of chemistry", artificial catalysis under physiologic conditions will be a new modal of medicine (catalysis medicine). I will present our recent results in: 1) (aerobic) oxidative coupling and peptide cleavage reactions through activation of stable molecules [1], 2) protecting group-minimum C˗C bond-forming asymmetric catalysis [2], and 3) organo-catalyzed visible light photo-oxygenation of amyloid beta (Ab) and its effects on aggregation properties and neurotoxicity of Abeta [3].
References
1. (a) Sonobe, T.; Oisaki, K.; Kanai, M. Chem. Sci. 2012, 3, 3249. (b) Seki, Y.; Tanabe, K.; Sasaki, D.; Sohma, Y.; Oisaki, K.; Kanai, M. Angew. Chem. Int. Ed. 2014, 53, 6501. (c) Ozawa, J.; Tashiro, M.; Ni, J.; Oisaki, K.; Kanai, M. Chem. Sci. 2016, 7, 1904. (d) Kuninobu, Y.; Ida, H.; Nishi, M.; Kanai, M. Nature Chem. 2015, 7, 712. (e) Nishida, T.; Ida, H.; Kuninobu, Y.; Kanai, M. Nature Commun. 2014, 5, 3387. (f) Tanabe, K.; Taniguchi, A.; Matsumoto, T.; Oisaki, K.; Sohma, Y.; Kanai, M. Chem. Sci. 2014, 5, 2747.
2. (a) Shi, S.-L.; Wei, X.-F.; Shimizu, Y.; Kanai, M. J. Am. Chem. Soc. 2012, 134, 17019. (b) Morita, Y.; Yamamoto, T.; Nagai, H.; Shimizu, Y.; Kanai, M. J. Am. Chem. Soc. 2015, 137, 7075. (c) X.-F. Wei, Y. Shimizu, M. Kanai, ACS. Cent. Sci. 2016, 2, 21. (d) Lin, L.; Yamamoto, K.; Mitsunuma, H.; Kanzaki, Y.; Matsunaga, S.; Kanai, M. J. Am. Chem. Soc. 2015, 137, 15418.
3. Taniguchi, A.; Sasaki, D.; Shiohara, A.; Iwatsubo, T.; Tomita, T.; Sohma, Y.; Kanai, M. Angew. Chem. Int. Ed. 2014, 53, 1382.