Organic Chemistry Seminar
In February 2007, we reported movies of the conformational change of a single organic molecule recorded on an atomic resolution transmission electron microscope (TEM).[i] This single-molecule atomic real-time TEM (SMART-TEM) movie of a single molecule provided the first demonstration of our ability to study the connectivity of carbon atoms and their time-dependent changes of single organic molecules and molecular clusters at atomic resolution. Below are illustrated the frames of a movie of a biotin derivative attached to the tip of a carbon nanotube moving slowly in vacuum.[ii] Fundamental science and applications will be discussed.
[i] M. Koshino, et al., Science, 316, 853 (2007). E. Nakamura, Angew. Chem. Int. Ed., 52, 236-252 (2013).
[ii] R.M. Gorgol, et al., J. Am. Chem. Soc., 137, 3474-3477 (2015).