Special Organic Chemistry Seminar - Organic Syntheses Lecture
Zoom available upon request. Sponsored by Organic Syntheses
Whereas recent advances in the field of Pd-catalyzed cross coupling have been driven largely by ligand and precatalyst design, coupled to insights into reaction mechanism, related studies for Ni have received less attention. For example, modern ligand frameworks designed for Pd and other precious metal catalysts (Rh, Ir) have been largely unsuccessful when applied to Ni. To address these needs, the Doyle lab has developed novel ligand classes and precatalysts for Ni and demonstrated that they enable new methodologies not previously possible with existing frameworks. Furthermore, our lab has sought to uncover the mechanistic basis for reactivity in a variety of Ni-catalyzed cross-coupling reactions through inorganic synthesis, kinetic analysis, computational studies, statistical modeling, and ultrafast and steady-state spectroscopy. This lecture will describe our recent efforts in these directions.