Organic Chemistry Seminar
Many potential drug targets are known to be relevant for disease, but have been 'undruggable' by current approaches. Our lab seeks to understand to what extent this failure has been due to the features of the biological target vs the methodologies used to discover small-molecule modulators. In particular, we have focused on protein-protein interactions and the larger networks controlled by these interactions. This seminar will describe our discoveries of first-in-class compounds with unusual mechanisms for inhibiting 'challenging' targets, including allosteric inhibitors of p97, protein-protein stabilizing compounds, and selective covalent inhibitors of proteases.