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Chemical Engineering Seminar

Thursday, November 21, 2019
4:00pm to 5:00pm
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Spalding Laboratory 106 (Hartley Memorial Seminar Room)
Towards holistic imaging and rapid phenotyping of complex biological systems
Kwanghun Chung, Assistant Professor, Chemical Engineering, Massachusetts Institute of Technology,

Holistic measurement of diverse functional, anatomical, and molecular traits that span multiple levels, from molecules to cells to an entire system, remains a major challenge in biology. In this talk, I will introduce a series of technologies including CLARITY (Chung, 2013), SWITCH (Murray, 2015), MAP (Ku, 2016), stochastic electrotransport (Kim, 2015), SHIELD (Park, 2019), and eFLASH (Yun, 2019) that enable integrated multiscale imaging and molecular phenotyping of both animal tissues and human clinical samples. I will discuss how we engineer (1) the physicochemical properties of biological tissues, (2) molecular interactions, and (3) molecular transport all together to achieve integrated organ-wide molecular phenotyping at unprecedented speed and resolution. I will also discuss how these tools can be deployed synergistically to study a broad range of biological questions. We hope that these new technologies will accelerate the pace of discovery in biomedical research.

For more information, please contact Sohee Lee by phone at 6263954193 or by email at sohee@caltech.edu.