DRAFT
Caltech Logo

Chemical Engineering Seminar

Thursday, November 10, 2022
4:00pm to 5:00pm
Add to Cal
Spalding Laboratory 106 (Hartley Memorial Seminar Room)
User-Programmable Hydrogel Biomaterials to Probe and Direct 4D Stem Cell Fate
Prof. Cole De Forest, Weyerhaeuser Endowed Professor and Associate Professor in the Departments of Chemical Engineering and Bioengineering, Departments of Chemical Engineering and Bioengineering, University of Washington,

The extracellular matrix directs stem cell function through a complex choreography of biomacromolecular interactions in a tissue-dependent manner. Far from static, this hierarchical milieu of biochemical and biophysical cues presented within the native cellular niche is both spatially complex and ever changing. As these pericellular reconfigurations are vital for tissue morphogenesis, disease regulation, and healing, in vitro culture platforms that recapitulate such dynamic environmental phenomena would be invaluable for fundamental studies in stem cell and organoid biology, as well as in the eventual engineering of functional human tissue. In this talk, I will discuss some of our group's recent successes in reversibly modifying both the chemical and physical aspects of synthetic cell culture platforms with user-defined spatiotemporal control, regulating cell-biomaterial interactions through user-programmable Boolean logic, engineering microvascular networks that span nearly all size scales of native human vasculature (including capillaries), and irreversibly photoassembling bioactive proteins within living cells. Results will highlight our ability to modulate intricate cellular behavior including stem cell differentiation, protein secretion, and cell-cell interactions in 4D.

For more information, please contact Sadie Rubalcava by phone at 6263953654 or by email at [email protected].