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Boehringer-Ingelheim Symposium

Monday, July 18, 2016
3:00pm to 4:00pm
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Noyes 153 (J. Holmes Sturdivant Lecture Hall)
Important Asymmetric and Catalytic Transformations for Drug Development
Chris H. Senanayake, Vice President, Chemical Development U.S., Department of Chemical Development, Boehringer-Ingelheim Pharmaceuticals, Inc.,

     During the past two decades, my process research group is involved in the development of a truly efficient, reliable, greener and economically viable catalytic and asymmetric transformations for many drugs and drug candidates.  Due to finding of effective asymmetric methodologies in a timely manner for important drug candidates, have provided many advantages to produce complex APIs in a rapidly for clinical development.  This lecture will be centered on several highlights of these methods for the synthesis of important drug candidates.

X. Wang, Y.  Xu, L. Zhang, D. Krishnamurthy, T.  Wirth, T. Nicola, and C. H. Senanayake, Org. Lett. 2010, 12, 4412; V. Farina, C. Shu, X. Zeng, X. Wei, Z. Han, N. Yee, C. Senanayake Org. Pro. Res. & Dev. 2009, 2, 250; Shu, C.; Zeng, X.; Hao, M.-H.; Wei, X.; Yee, N. K.; Busacca, C. A.; Han, Z.; Farina, V.; Senanayake, C. H.   Org. Lett.  2008,  10,  1303; Busacca, C.A.: Lorenz, J.C.; Grinberg, N.; Haddad, N.; Lee, H.; Li, Z.; Liang, M.; Reeves, D.; Saha, A.; Varsolona, R.; Senanayake, C.H.  Org. Lett. 2008, 10(2), 341; Jon C. Lorenz, Carl A. Busacca, XuWu Feng, Nelu Grinberg, Nizar Haddad, Joe Johnson, Suresh Kapadia, Heewon Lee, Anjan Saha, Max Sarvestani, Earl M. Spinelli, Rich Varsolona, Xudong Wei, Xingzhong Zeng and Chris H. Senanayake. J. Org. Chem., 2010, 75, 1155; Angew. Chem. Int. Ed. 2010, 122, 6015; J. Am. Chem. Soc. 2010, 132, 7600. Han, Zhengxu S.; Herbage, Melissa A.;Mangunuru, Hari P. R.; Xu, Yibo; Zhang, Li; Reeves, Jonathan T.; Sieber, Joshua D.; Li, Zhibin; DeCroos, Philomen; Zhang, Yongda Angew. Chem. Int. Ed. 2013, 52(26), 6713-6717; Han Zhengxu S; Goyal Navneet; Herbage Melissa A; Sieber Joshua D; Qu Bo; Xu Yibo; Li Zhibin; Reeves Jonathan T; Desrosiers Jean-Nicolas; Ma Shengli J. Am. Chem. Soc. 2013, 135, 2474.

For more information, please contact Lynne Martinez by phone at 626-395-4004 or by email at [email protected].