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Caltech

Boehringer-Ingelheim Lecture

Wednesday, December 12, 2018
4:00pm to 5:00pm
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Noyes 153 (J. Holmes Sturdivant Lecture Hall)
Recent Efforts in the Synthesis of Complex Natural Products: The Evolution of Strategies for the Syntheses of Aspergilline A and Herquline B
John Wood, Professor, Department of Chemistry & Biochemistry, Baylor University,

Aspergilline A was isolated in 2014 by Hu and Gao from Aspergillis versicolor and found to have activity against a variety of cancer cell lines with IC-50's in the low micromolar range.  Herquline B, along with a ring closed congener, herquline A, were isolated by ┼îmura and co-workers in 1996 and 1979, respectively. In contrast to aspergilline A, the herqulines were found to posses inhibitory properties against platelet aggregation and the influenze virus.  The evolution of strategies for the stereoselective syntheses of aspergilline A and herquline B will be presented.

For more information, please contact Annette Luymes by phone at 626-395-6016 or by email at [email protected].