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Caltech

Organic Chemistry Seminar

Wednesday, October 30, 2013
4:00pm to 5:00pm
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Noyes 153 (J. Holmes Sturdivant Lecture Hall)
Catalytic Asymmetric Molecular Rearrangements
Uttam K. Tambar, Assistant Professor, Biochemistry Department, University of Texas Southwestern Medical Center,

     Our group is interested in discovering new catalytic asymmetric rearrangements, which are synthetically powerful chemical transformations for the assembly of complex molecules.  We have developed a series of enantioselective [2,3]-rearrangements, including an allylic amination of unactivated olefins via a [2,3]-rearrangement and a Meisenheimer rearrangement of allylic amine N-oxides.  Our efforts in this area have provided new insight into the mechanisms of catalytic [2,3]- rearrangements.  We are guided by the mechanistic hypothesis that reactive zwitterionic intermediates can be subjected to catalytic stereoselective rearrangements, despite their propensity to undergo facile thermal sigmatropic rearrangements.

For more information, please contact Arleen (Lynne) Martinez by phone at 626-395-4004 or by email at [email protected].