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Organic Chemistry Seminar

Wednesday, September 4, 2019
4:00pm to 5:00pm
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Noyes 153 (J. Holmes Sturdivant Lecture Hall)
Construction and Deconstruction of Three-Dimensional Molecules
Thomas Magauer, Professor, Chemistry and Biomedicine, Leopold-Franzens-University Innsbruck,

Natural products constitute a vast and largely unexplored library of complex molecular architectures, and are a fundamental source for novel bioactive agents. However, the complex architecture of these molecules often prevents their application in medicinal chemistry. For us, this is an inspiration to think about innovative retrosynthetic bond disconnections which enable rapid access to the target compounds. We want to discover, design and develop powerful transformations such as cationic cyclizations and ring-expansions and apply them to the synthesis of biologically relevant complex natural products and simplified analogs thereof. The goal of these projects is to shed light on proposed biosynthetic processes, to identify new molecular targets and ultimately provide new lead compounds for the treatment of human diseases.

For more information, please contact Annette Luymes by phone at 626-395-6016 or by email at aluymes@caltech.edu.