Caltech Math for the Win

March has been a good month for Caltech mathematics. For the first time since 1983, Caltech placed first in the Mathematical Association of America's William Lowell Putnam Competition, one of the premier undergraduate mathematics contests. Also this past month, Michael Aschbacher, the Shaler Arthur Hanisch Professor of Mathematics, was awarded the Rolf Schock Prize in Mathematics.

Caltech finished third and fifth in the Putnam Competition in the last two years, respectively. But this year, the team of senior Jason Bland, senior Yakov Berchenko-Kogan, and junior Brian Lawrence beat out perennial powerhouses MIT and Harvard for the win. Caltech's math department is awarded $25,000 for the top finish, and each team member receives $1,000. Lawrence finished in the top five, winning another $2,500, and was named a Putnam Fellow for a third time—one of only 19 three-time fellows. Bland was a fellow in 2007. Past Putnam Fellows include Richard Feynman (1939) and Caltech's IBM Professor of Mathematics and Theoretical Physics Barry Simon (1965).

Berchenko-Kogan and Bland, as well as junior Zarathustra Brady, placed in the top 24, receiving $250. Senior Timothy Black, junior Sam Elder, junior Jeffrey Manning, and senior Gjergji Zaimi earned honorable mentions. About 40 Caltech students participated in the contest, which took place back in December. A total of 4,296 students from 546 colleges and universities from the United States and Canada competed.

Taking place every year since 1938, the Putnam Competition is a two-part written test in which participants have a total of six hours to tackle 12 problems. Caltech has won the competition 10 times, second only to Harvard (27). Caltech has also finished in the top five 31 times, behind MIT (41) and Harvard (56).

Aschbacher won the Rolf Schock Prize "for his fundamental contributions to one of the largest mathematical projects ever, the classification of finite simple groups, notably his contribution to the quasi-thin case," according to the award citation.

Groups are one of the most fundamental objects in mathematics. You can rotate an equilateral triangle once, twice, or three times, and the triangle still looks the same. Likewise, you can rotate a dodecahedron in 60 distinct ways, and it won't look different (see the shape on the right of the top image). These rotational symmetries for the triangle and dodecahedron both form simple groups, which contain three and 60 elements, respectively.

All groups can be built from so-called finite simple groups, and over the last few decades, Aschbacher has played a leading role in constructing and determining all of the finite simple groups—a daunting task to say the least. For example, proving that the list of finite simple groups was complete took over 5,000 pages, says Barry Simon. "Many people regard it as the most complicated single result in mathematics."

Most of the finite simple groups were classified by around 1980, but mathematicians realized that there was a gap in the list, called the "quasi-thin case." Finally, in 2004, Aschbacher and Stephen Smith of the University of Illinois at Chicago completed the proof in two books that span more than 1,200 pages.

The Schock mathematics prize is awarded by the Royal Swedish Academy of Sciences and includes $75,000. Perhaps the most famous previous winner is Andrew Wiles, who proved Fermat's Last Theorem and won the prize in 1995. Founded in 1993, the Rolf Schock Prizes were awarded every two years until 2008, when they became triennial awards. The prizes are also given in the fields of logic and philosophy, visual arts, and music.

Marcus Woo
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Ellis Awarded Gold Medal

Richard Ellis, the Steele Family Professor of Astronomy, has received the Gold Medal of the Royal Astronomical Society. Awarded annually since 1824, the Gold Medal is the society's highest honor and one of the premier prizes in astronomy. Ellis joins a long list of distinguished recipients, including several from Caltech: Don Anderson, Peter Goldreich, Gerald Wasserburg, Maarten Schmidt, Fritz Zwicky, Jesse Greenstein, Ira Bowen, and George Ellery Hale.

According to the London-based society's award citation, "[Ellis] has been one of the most influential British astronomers in the past thirty years," and the Gold Medal recognizes his "outstanding personal research achievements and his leadership in astronomy." Ellis's research focuses on the large-scale distribution of matter in the universe; the cosmic expansion history; and the evolution of galaxies, through detailed studies of nearby systems and the exploration of the very earliest objects. After Ellis joined Caltech's faculty in 1999, the latter observations were accomplished in large part at the Keck Observatory.

"We are very proud that Richard continues the long tradition of outstanding achievement in astronomy at Caltech," says Tom Soifer, professor of physics and chair of the Division of Physics, Mathematics and Astronomy.

As a scientific mentor, Ellis has supervised 30 PhD students; 28 are still active in academic research. He served as director of the Palomar Observatory (now Caltech Optical Observatories) from 2000 to 2005 and has played an important role in building the science case and partnership for the upcoming Thirty Meter Telescope.

He has received several other honors, including sharing the Peter and Patricia Gruber Foundation's Cosmology Prize for his part in the discovery of the accelerating universe and the Royal Astronomical Society's Group Achievement Award for his leadership in the 2-degree-Field Galaxy Redshift Survey, one of the largest astronomical surveys ever performed. Ellis was made a Commander of the British Empire by Queen Elizabeth II for services to international science, and he is a fellow of the Royal Society, the American Association for the Advancement of Science, and the Institute of Physics.

Marcus Woo
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Astronomers Discover Close-knit Pairs of Massive Black Holes

PASADENA, Calif.—Astronomers at the California Institute of Technology (Caltech), University of Illinois at Urbana-Champaign (UIUC), and University of Hawaii (UH) have discovered 16 close-knit pairs of supermassive black holes in merging galaxies.

The discovery, based on observations done at the W. M. Keck Observatory on Hawaii's Mauna Kea, is being presented in Seattle on January 12 at the meeting of the American Astronomical Society, and has been submitted for publication in the Astrophysical Journal.

These black-hole pairs, also called binaries, are about a hundred to a thousand times closer together than most that have been observed before, providing astronomers a glimpse into how these behemoths and their host galaxies merge—a crucial part of understanding the evolution of the universe. Although few similarly close pairs have been seen previously, this is the largest population of such objects observed as the result of a systematic search.

"This is a very nice confirmation of theoretical predictions," says S. George Djorgovski, professor of astronomy, who will present the results at the conference. "These close pairs are a missing link between the wide binary systems seen previously and the merging black-hole pairs at even smaller separations that we believe must be there."

As the universe has evolved, galaxies have collided and merged to form larger ones. Nearly every one—or perhaps all—of these large galaxies contains a giant black hole at its center, with a mass millions—or even billions—of times higher than the sun’s. Material such as interstellar gas falls into the black hole, producing enough energy to outshine galaxies composed of a hundred billion stars. The hot gas and black hole form an active galactic nucleus, the brightest and most distant of which are called quasars. The prodigious energy output of active galactic nuclei can affect the evolution of galaxies themselves.
While galaxies merge, so should their central black holes, producing an even more massive black hole in the nucleus of the resulting galaxy. Such collisions are expected to generate bursts of gravitational waves, which have yet to be detected. Some merging galaxies should contain pairs of active nuclei, indicating the presence of supermassive black holes on their way to coalescing. Until now, astronomers have generally observed only widely separated pairs—binary quasars—which are typically hundreds of thousands of light-years apart.

"If our understanding of structure formation in the universe is correct, closer pairs of active nuclei must exist," adds Adam Myers, a research scientist at UIUC and one of the coauthors. "However, they would be hard to discern in typical images blurred by Earth's atmosphere."

The solution was to use Laser Guide Star Adaptive Optics, a technique that enables astronomers to remove the atmospheric blur and capture images as sharp as those taken from space. One such system is deployed on the W. M. Keck Observatory's 10-meter telescopes on Mauna Kea.

The astronomers selected their targets using spectra of known galaxies from the Sloan Digital Sky Survey (SDSS). In the SDSS images, the galaxies are unresolved, appearing as single objects instead of binaries. To find potential pairs, the astronomers identified targets with double sets of emission lines—a key feature that suggests the existence of two active nuclei.

By using adaptive optics on Keck, the astronomers were able to resolve close pairs of galactic nuclei, discovering 16 such binaries out of 50 targets. "The pairs we see are separated only by a few thousands of light-years—and there are probably many more to be found," says Hai Fu, a Caltech postdoctoral scholar and the lead author of the paper.

"Our results add to the growing understanding of how galaxies and their central black holes evolve," adds Lin Yan, a staff scientist at Caltech and one of the coauthors of the study.

“These results illustrate the discovery power of adaptive optics on large telescopes,” Djorgovski says. “With the upcoming Thirty Meter Telescope, we’ll be able to push our observational capabilities to see pairs with separations that are three times closer.”

In addition to Djorgovski, Fu, Myers, and Yan, the team includes Alan Stockton from the University of Hawaii at Manoa. The work done at Caltech was supported by the National Science Foundation and the Ajax Foundation.

Images of some of the merging systems are available at

Marcus Woo

Make Your Own Flake

With little more than a plastic soda bottle, some fishing line, a sponge, and dry ice, anyone can make it snow, make it snow, make it flake at a time.

So says Caltech physicist-turned-snowflake-guru Ken Libbrecht, who recently walked listeners of NPR's Science Friday through a do-it-yourself snowflake-making tutorial.

The home-grown snowmaking process tends to differ from what goes on in a cloud, relying on water vapor rather than water droplets. But, in the end, creating flakes is about humidity and temperature, with the shape of the crystal depending in large part on how cold it is where it forms.

And, it turns out, snowflakes are picky about the temperatures at which they'll grow; not every spot on the snowflake-growing fishing line is conducive to creating a crystal. Why not? "It's not understood at all," Libbrecht says, "why the growth of ice depends so sensitively on temperatures." Indeed, that's one of the mysteries Libbrecht is studying in his Caltech lab, where the snowflake growing may be higher-tech, but no less entrancing, than in a soda bottle.

Want to try this at home? You can check out Libbrecht's recipe for creating a white Christmas—yes, even in Southern California—at his Snow Crystals website.

Lori Oliwenstein
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Caltech Physicists Demonstrate a Four-Fold Quantum Memory

PASADENA, Calif. — Researchers at the California Institute of Technology (Caltech) have demonstrated quantum entanglement for a quantum state stored in four spatially distinct atomic memories.

Their work, described in the November 18 issue of the journal Nature, also demonstrated a quantum interface between the atomic memories—which represent something akin to a computer "hard drive" for entanglement—and four beams of light, thereby enabling the four-fold entanglement to be distributed by photons across quantum networks. The research represents an important achievement in quantum information science by extending the coherent control of entanglement from two to multiple (four) spatially separated physical systems of matter and light.

The proof-of-principle experiment, led by William L. Valentine Professor and professor of physics H. Jeff Kimble, helps to pave the way toward quantum networks. Similar to the Internet in our daily life, a quantum network is a quantum "web" composed of many interconnected quantum nodes, each of which is capable of rudimentary quantum logic operations (similar to the "AND" and "OR" gates in computers) utilizing "quantum transistors" and of storing the resulting quantum states in quantum memories. The quantum nodes are "wired" together by quantum channels that carry, for example, beams of photons to deliver quantum information from node to node. Such an interconnected quantum system could function as a quantum computer, or, as proposed by the late Caltech physicist Richard Feynman in the 1980s, as a "quantum simulator" for studying complex problems in physics.

Quantum entanglement is a quintessential feature of the quantum realm and involves correlations among components of the overall physical system that cannot be described by classical physics. Strangely, for an entangled quantum system, there exists no objective physical reality for the system's properties. Instead, an entangled system contains simultaneously multiple possibilities for its properties. Such an entangled system has been created and stored by the Caltech researchers.

Previously, Kimble's group entangled a pair of atomic quantum memories and coherently transferred the entangled photons into and out of the quantum memories ( For such two-component—or bipartite—entanglement, the subsystems are either entangled or not. But for multi-component entanglement with more than two subsystems—or multipartite entanglement—there are many possible ways to entangle the subsystems. For example, with four subsystems, all of the possible pair combinations could be bipartite entangled but not be entangled over all four components; alternatively, they could share a "global" quadripartite (four-part) entanglement.

Hence, multipartite entanglement is accompanied by increased complexity in the system. While this makes the creation and characterization of these quantum states substantially more difficult, it also makes the entangled states more valuable for tasks in quantum information science.

To achieve multipartite entanglement, the Caltech team used lasers to cool four collections (or ensembles) of about one million Cesium atoms, separated by 1 millimeter and trapped in a magnetic field, to within a few hundred millionths of a degree above absolute zero. Each ensemble can have atoms with internal spins that are "up" or "down" (analogous to spinning tops) and that are collectively described by a "spin wave" for the respective ensemble. It is these spin waves that the Caltech researchers succeeded in entangling among the four atomic ensembles.

The technique employed by the Caltech team for creating quadripartite entanglement is an extension of the theoretical work of Luming Duan, Mikhail Lukin, Ignacio Cirac, and Peter Zoller in 2001 for the generation of bipartite entanglement by the act of quantum measurement. This kind of "measurement-induced" entanglement for two atomic ensembles was first achieved by the Caltech group in 2005 (

In the current experiment, entanglement was "stored" in the four atomic ensembles for a variable time, and then "read out"—essentially, transferred—to four beams of light. To do this, the researchers shot four "read" lasers into the four, now-entangled, ensembles. The coherent arrangement of excitation amplitudes for the atoms in the ensembles, described by spin waves, enhances the matter–light interaction through a phenomenon known as superradiant emission.

"The emitted light from each atom in an ensemble constructively interferes with the light from other atoms in the forward direction, allowing us to transfer the spin wave excitations of the ensembles to single photons," says Akihisa Goban, a Caltech graduate student and coauthor of the paper. The researchers were therefore able to coherently move the quantum information from the individual sets of multipartite entangled atoms to four entangled beams of light, forming the bridge between matter and light that is necessary for quantum networks.

The Caltech team investigated the dynamics by which the multipartite entanglement decayed while stored in the atomic memories. "In the zoology of entangled states, our experiment illustrates how multipartite entangled spin waves can evolve into various subsets of the entangled systems over time, and sheds light on the intricacy and fragility of quantum entanglement in open quantum systems," says Caltech graduate student Kyung Soo Choi, the lead author of the Nature paper. The researchers suggest that the theoretical tools developed for their studies of the dynamics of entanglement decay could be applied for studying the entangled spin waves in quantum magnets.

Further possibilities of their experiment include the expansion of multipartite entanglement across quantum networks and quantum metrology. "Our work introduces new sets of experimental capabilities to generate, store, and transfer multipartite entanglement from matter to light in quantum networks," Choi explains. "It signifies the ever-increasing degree of exquisite quantum control to study and manipulate entangled states of matter and light."

In addition to Kimble, Choi, and Goban, the other authors of the paper, "Entanglement of spin waves among four quantum memories," are Scott Papp, a former postdoctoral scholar in the Caltech Center for the Physics of Information now at the National Institute of Standards and Technology in Boulder, Colorado, and Steven van Enk, a theoretical collaborator and professor of physics at the University of Oregon, and an associate of the Institute for Quantum Information at Caltech.

This research was funded by the National Science Foundation, the National Security Science and Engineering Faculty Fellowship program at the U.S. Department of Defense (DOD), the Northrop Grumman Corporation, and the Intelligence Advanced Research Projects Activity.

Marcus Woo

Eugene W. Cowan, 90

PASADENA, Calif.—Eugene W. "Bud" Cowan, professor of physics, emeritus, at the California Institute of Technology (Caltech), passed away November 4 in Menlo Park, California. He was 90.

Cowan's research interests included investigations of high-energy interactions of cosmic rays, air-pollution studies, and studies of the earth's magnetism. He was noted for perfecting a cloud chamber capable of operating on a continuous basis. All cloud chambers depend on the condensation of a vapor on the charged ions left by the passage of a speeding particle. Previous cloud chambers had required a sudden, large drop in chamber pressure for condensation to occur, and this had to be followed by a rest period during which no observations could be made. Cowan's innovation eliminated the need for the pressure decrease and thus eliminated the rest period.

Cowan was particularly proud of his work in the early 1950s on the Xi "cascade" particle, the first doubly strange baryon. His cloud-chamber image clearly confirmed the existence of the particle and provided important input that led to the subsequent development of the quark model. His later work focused on the dynamics of the mechanism that generates the earth's magnetic field.

Long recognized for the quality of his teaching, Cowan received the 1986 Associated Students of the California Institute of Technology (ASCIT) Award for Teaching Excellence for his course on classical electromagnetism.

Cowan was born in 1920 in Ree Heights, South Dakota. After receiving his BS at the University of Missouri and his SM at MIT, where he was an instructor in the radar school and at the Radiation Laboratory, he came to Caltech in 1945. Cowan studied under cosmic-ray researcher and Nobel Laureate Carl Anderson. Awarded his PhD in 1948, Cowan became a research fellow in 1948, an assistant professor in 1950, and an associate professor in 1954. In 1961 he was promoted to professor of physics and became an emeritus professor in 1986.

Cowan was awarded four patents, including one for his innovative cloud chamber. He was a fellow of the American Physical Society.

In the Caltech community, Cowan was well known for his regular visits to the Caltech pool. "My father also walked the 2 1/2 miles to and from work for probably more than 50 years, and for much of that time also went daily to the Caltech pool and gym," says his son, Glen, a particle physicist at Royal Holloway, University of London. "His favorite hobby was hiking in the San Gabriel Mountains, and he was often one of the small group of hikers that walked to the physics picnic from the trail head in Sierra Madre. My father truly enjoyed being part of the Caltech community. I believe he was there almost every day from 1945 to 2008. Maybe that's some kind of record." 

In 2008, Cowan and his wife, Thelma, moved from Pasadena to Menlo Park, California, to be near their daughter,  Tina, a geneticist at Stanford University.

Cowan is survived by his wife of 54 years, Thelma Rasmussen Cowan; daughter Tina Cowan Hiltbrand and son Glen Cowan; and grandchildren David and Karin Hiltbrand. 

Kathy Svitil
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Discovering New Worlds

A Conversation with John Johnson

What's the focus of your research?

Broadly speaking, we want to find new planets around other stars, which are commonly referred to as exoplanets. We're building up a huge statistical sample. When you have a large number of planets, you can start looking for patterns, trends, and hints about the planet-formation process. The primary goal of my search for planets is to understand planet formation and therefore to understand the origins of the solar system. My characterization work is focused on individual systems of planets or the planets themselves. We're trying to learn about their physical characteristics, such as their radii, masses, average densities, and atmospheric properties. For systems of planets, we're interested in how planets interact gravitationally with one another. The exact nature of those gravitational interactions gives us hints about how planetary orbits evolve after they form. And that probably has a lot to do with how architectures of planetary systems eventually come to be.

What about this field is exciting?

It gets me out of bed every morning. I literally can't wait to see the latest data. It happened to me just yesterday. I was observing remotely in the basement of Cahill until my collaborators relieved me at about 3 a.m., since I had a full workday the next day and needed to sleep. I went to bed at about 3:30, expecting to sleep until 10:30. But I woke up at 7:30 and started thinking, you know, we just observed this new system we found and it's really wacky. It's a hot Jupiter around a type of star that's not supposed to have any hot Jupiters. If this next observation falls on the predicted curve, and it's likely going to be very real, then I'm going to have to think about how to share this with everybody. I couldn't go back to sleep. I was bone-tired, but I was excited and hyped up, so I got up and started working on the paper.

An artist's rendering of a gas-giant exoplanet orbiting a so-called subgiant star.
Credit: NASA/ESA/G. Bacon (STScl).

I don't know if I would get that level of excitement if I were doing cosmology or if I were studying galaxies—not to say that those fields are not immensely important and have exciting results. I just see new things every day that nobody on Earth has ever seen. It's just really fun being in a field of astronomy that's in its infancy—and being in a place like Caltech where we have Keck access once a month and we can actually watch all this happen.

What got you interested in science in general?

Stephen Hawking. A Brief History of Time—it changed my life. It's kind of clichéd. Half of all physicists are in physics because of that book. That's definitely what got me. Other popular-physics books after that sealed the deal. I was an engineer when I started off as an undergrad, doing aerospace and mechanical engineering. But it wasn't as interesting as discovering things about the universe.

But it all started in college. I can't say that I was one of those kids who begged their dad to buy them a telescope and then used it in their backyards. I had zero interest in astronomy until late in my college career. I was the kid who stayed inside and played with his Legos instead of the kid who went outside and explored under rocks. I was an engineer.

Why should we care about finding exoplanets? They don't plug up oil spills.

Every astronomer goes through that existential crisis. You have to understand that our society as we know it today is shaped largely through a lot of different astrophysical discoveries. The fact that we know Earth orbits the sun came from astronomers 450 years ago. The work that we're doing today is going to impact our culture and our understanding of our place in the universe forever. It's going to happen slowly, but that's what we're in the business of doing. Exoplanets are really good for that because we live on a planet, and we are finding other planets. We're trying to understand the planet we live on—where did it come from? It's the ultimate origin story. We are coming out of the darkness from a couple hundred years ago and we're rubbing our eyes today, realizing that we are on a really small planet around a really average star in an unspectacular part of the galaxy, and we're learning our place in this whole universe. Once we find more planets like our own, it'll further define our place and give us a better universal context for what it means to be human.

Read the full interview in E&S online.

Marcus Woo

Ralph W. Kavanagh, 86

Ralph W. Kavanagh, professor of physics, emeritus, at the California Institute of Technology (Caltech) passed away August 16 in Pasadena, California. He was 86.

Kavanagh was an expert in nuclear physics, primarily focusing on nuclear energy generation within the sun. As a member of Caltech's Kellogg Radiation Laboratory, he performed experiments looking at the fundamental interactions of light nuclei. He helped test some of the first models of evolving stars, which were based on his efforts to measure nuclear reactions thought to occur in the core of the sun.

Kavanagh focused on the steps in the chain that lead to the production of beryllium-7 and ultimately to the emission of neutrinos, the only particles that can escape unscathed from the center of the sun.  These neutrinos carry information about the solar interior and detecting them has become an active branch of astrophysics.  Kavanagh played a prominent role in this subfield through his careful studies of the properties of chlorine-37 and argon-37, the two nuclei involved in the detection of solar neutrinos that reach the earth.

In addition to the usual handful of graduate students he mentored, Kavanagh also taught the Advanced Physics Lab, beginning in the early 1970s and continuing until his retirement in 2000. This two-term course was required of all seniors majoring in physics; the few students committed to a theoretical career were permitted to substitute a thesis instead.  In this lab, Kavanagh followed the pattern established by Caltech physicist Victor Neher, with all exams being a private oral grilling at the conclusion of each experiment. In this fashion, Kavanagh came to know his physics students well and served them as a graduate-school advisor.

Born in 1924 in Seattle, Washington, Kavanagh served in the U.S. Navy from 1942 to 1946 before receiving his BA from Oregon's Reed College in 1950, followed by his MA from the University of Oregon. He received his PhD from Caltech in 1956. He continued at Caltech as a research fellow from 1956 to 1958, eventually becoming full professor in 1970. He became emeritus in 2000.

He was a fellow of the American Physical Society and the American Association for the Advancement of Science.

Outside the classroom, Kavanagh was an ardent classical pianist who was also fond of playing Ping-Pong. He enjoyed sailing and completing crossword puzzles, which he often could do in his head. An avid outdoorsman, he also enjoyed camping and hiking.

His family says he will be remembered for his sharp wit and wry sense of humor, for his high standard of ethics and his compassion for those less fortunate, and for his love of nature.

"Above all, science was not only his career, but his passion and hobby," says his wife, Joyce.

He leaves behind his wife, Joyce Kavanagh; daughters Kathleen Kavanagh, Janet Kavanagh, Stephanie Kavanagh Harlan, and Linda Kavanagh; eight grandchildren, and one great-grandson. His son, William Kavanagh, predeceased him. 

A service will be held at 10 a.m. on October 25, 2010, at the Athenaeum on the Caltech campus.

Jon Weiner
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Two Caltech Scientists Receive 2010 NIH Director's Pioneer Awards

Michael Roukes, Pamela Bjorkman recognized for their "highly innovative approaches" to biomedical research

PASADENA, Calif.—Two scientists from the California Institute of Technology (Caltech) have been recognized by the National Institutes of Health (NIH) for their innovative and high-impact biomedical research programs.

Michael Roukes, professor of physics, applied physics, and bioengineering, and co-director of the Kavli Nanoscience Institute, and

Pamela Bjorkman, Caltech's Max Delbrück Professor of Biology and a Howard Hughes Medical Institute investigator, now join the 81 Pioneers—including Caltech researchers Rob Phillips and Bruce Hay—who have been selected since the program's inception in 2004.

"NIH is pleased to be supporting scientists from across the country who are taking considered risks in a wide range of areas in order to accelerate research," said NIH Director Francis S. Collins in announcing the awards. "We look forward to the result of their work."

According to its website, the program provides each investigator chosen with up to $500,000 in direct costs each year for five years to pursue what the NIH refers to as "high-risk research," and was created to "support individual scientists of exceptional creativity who propose pioneering—and possibly transforming—approaches to major challenges in biomedical and behavioral research."

For Roukes, that means using "nanoscale tools to push biomedical frontiers." Specifically, he plans to leverage advances in nanosystems technology, "an approach that coordinates vast numbers of individual nanodevices into a coherent whole," he explains.

The goal? To create tiny "chips" that can be used to rapidly identify which specific bacteria are plaguing an individual patient—quickly, at the patient's bedside, and without the need for culturing. Similar chips, he says, will be capable of "obtaining physiological 'fingerprints' from exhaled breath" for use in disease diagnostics.

Roukes says the chips will also provide new approaches to cancer research through the analysis of cell mechanics and motility, and will provide less-costly ways to screen libraries of therapeutic drug candidates. Roukes's highly collaborative efforts are aimed at jump-starting what he calls a "nanobiotech incubator" at Caltech.

Roukes received his PhD in physics in 1985 from Cornell University. He has been at Caltech since 1992, and was named founding director of the Kavli Nanoscience Institute in 2004.

Bjorkman's Pioneer project will focus on ways to improve the human immune response to HIV. "HIV/AIDS remains one of the most important current threats to global public health," she says. "Although humans can mount effective immune responses using antibodies against many other viruses, the antibody response to HIV in infected individuals is generally ineffective."

This, she believes, is the result of the "unusually low number and low density of spikes" on the surface membrane of the virus. Antibodies have two identical "arms" with which to attach to a virus or bacterium. In most cases, the density of spikes on a pathogen's surface is high enough that these arms can simultaneously attach to neighboring spikes. Not so with HIV; because its spikes are so few and far between, antibodies tend to bind with only one arm attaching to a single spike. Such binding is weak, says Bjorkman, "much like if you were hanging from a bar with only one arm," and is easily eliminated by viral mutations.

That is why Bjorkman is proposing "a new methodology, designed to screen for and produce novel anti-HIV binding proteins that can bind simultaneously to all three monomers in an HIV spike trimer." A trimer is a protein made of three identical macromolecules; if an antibody can bind to all three proteins at one time, it will "interact very tightly and render the low spike density of HIV and its high mutation rate irrelevant to effective neutralization," Bjorkman explains.

Bjorkman received her PhD in biochemistry and molecular biology in 1984 from Harvard University. She has been at Caltech since 1989, and was named the Delbrück Professor in 2004.

Lori Oliwenstein
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LISA Gravitational-Wave Mission Strongly Endorsed by National Research Council

PASADENA, Calif. — The National Research Council (NRC) has strongly recommended the Laser Interferometer Space Antenna (LISA) as one of NASA's next two major space missions, to start in 2016 in collaboration with the European Space Agency (ESA). LISA will study the universe in a manner different from any other space observatory, by observing gravitational waves. The recommendation was announced August 13 in a press conference at the Keck Center of the National Academies in Washington, D.C. 

In the just-concluded "Astro2010" decadal survey, a panel of experts was convened to look at the coming decade and prioritize all research activities in astronomy and astrophysics, as well as at the interface of these disciplines with physics. The survey recommended LISA highly because of the expectation that observations of gravitational waves in space will answer key scientific questions about the astrophysics of the cosmic dawn and the physics of the universe.

"We are very pleased with the NRC's recognition of LISA's extraordinary research opportunities in astrophysics and fundamental physics," says Tom Prince, professor of physics at the California Institute of Technology (Caltech), senior research scientist at the Jet Propulsion Laboratory (JPL), and the U.S. chair of the LISA International Science Team. Scientists from many European countries participate in LISA either as members of the science team or as members of the LISA International Science Community. "We are looking forward to unveiling a new window on the universe by observing thousands of gravitational wave sources." 

"This recommendation and our excellent reputation in the scientific community encourages us a lot. With LISA we will open up an entirely new way of observing the universe, with immense potential to enlarge our understanding of physics and astronomy in unforeseen ways," says Karsten Danzmann, European chair of the LISA International Science Team.

"In the past it has sometimes been difficult to get mainstream astronomers to recognize the importance of gravitational wave astronomy," says Marcia Rieke, a professor of astronomy at the University of Arizona and vice chair for the Astro2010 subcommittee on programs. "The ranking of LISA is an indication that astronomers are recognizing the opportunities that LISA presents for using gravitational waves to study the universe in a new way." 

"The science case for LISA has become much richer over the last 10 years. On the experimental side, a similar story could be made that what were once novel measurement concepts are now reliable, proven technologies," says LISA science team member Scott Hughes, associate professor of physics at the Massachusetts Institute of Technology. 

"In the 13 years I've been involved with LISA, its technology and science have advanced beyond my wildest first dreams," says Sterl Phinney, professor of theoretical astrophysics at Caltech, current co-chair of the sources and data analysis working group of the LISA science team, and chair of the original LISA Mission Definition Team. "I'm looking forward to its precise measurements telling us if the giant black holes in the centers of galaxies really follow the rules of Einstein's theory of general relativity, and which if any of the ideas about how they get made are correct." 

"This strong endorsement by America's leading astronomers makes it official: LISA has the potential to become one of the most important astronomical observatories of our time," says Bernard F. Schutz, director of the Max Planck Institute for Gravitational Physics (Albert Einstein Institute/AEI) in Potsdam, Germany and co-chair of the sources and data analysis working group of the LISA science team. 

"When LISA was adopted by the ESA in 1995, it was because its observations of gravitational waves would provide powerful insight into the fundamentals of gravity, of Einstein's theory and all its predictions," adds Schutz. "In the last 15 years, astronomers also have learned how LISA can open up hidden chapters in the history of the universe, by listening to the waves made by the very first stars, the earliest black holes, and by some of the oldest stars in existence today. By seeing how the waves from early black holes are stretched out as they move toward us through the expanding universe, LISA can even study the mysterious dark energy."

LISA is designed to be complementary to the ground-based observatories (the Laser Interferometer Gravitational-Wave Observatory, or LIGO, in the United States, and Virgo and GEO-600 in Europe) that currently are actively searching for signs of gravitational waves; both search for ripples in the fabric of space and time formed by the most violent events in the universe, such as the coalescence of black holes, that carry with them information about their origins and about the nature of gravity that cannot be obtained using conventional astronomical tools. The existence of the waves was predicted by Albert Einstein in 1916 in his general theory of relativity.

The LISA instrument will consist of three spacecraft in a triangular configuration with 5-million-kilometer arms (12.5 times the distance from the Earth to the moon), moving in an Earth-like orbit around the sun. Gravitational waves from sources throughout the universe will produce slight oscillations in the arm lengths (changes as small as about 10 picometers, or 10 million millionths of a meter, a length smaller than the diameter of the smallest atom). LISA will capture these motions—and thus measure the gravitational waves—using laser links to monitor the displacements of gold–platinum test masses floating inside the spacecraft. It is slated for launch in the early 2020s. 

LISA will observe gravitational waves in a lower frequency band (0.1 milliHertz to 1 Hertz) than that detectable by LIGO and other ground-based instruments, which are designed to sense sources at frequencies above 10 Hertz.

Because gravitational waves are moving ripples in the curvature of space, and because LISA will sense ripples coming simultaneously from tens of thousands of sources in every direction, the instrument acts more like a microphone listening to sound than like a telescope or a camera taking a picture. This new kind of observing tells us directly about the motion of invisible masses, complementing traditional astronomical observations of light, which reveal only visible atoms.

In the U.S. the LISA project is managed by the NASA Goddard Space Flight Center and includes significant participation by JPL, which is managed by Caltech for NASA. 

LISA's hardware will get its first test in space with the launch of LISA Pathfinder by 2013. This will include a thorough test of a crucial component of LISA's technology: drag-free operation, whereby the spacecraft shield the test masses from external disturbances by precisely monitoring their motions and moving around them to preserve their free fall. LPF recently reached a key phase of development, during which the flight hardware undergoes rigorous pre-flight testing.

Kathy Svitil