Caltech Faculty Elected to the American Academy of Arts and Sciences

The American Academy of Arts and Sciences has elected three Caltech faculty members as academy fellows. They are John F. Brady, Chevron Professor of Chemical Engineering and Mechanical Engineering and executive officer for chemical engineering; Kenneth A. Farley, W. M. Keck Foundation Professor of Geochemistry and chair of the Division of Geological and Planetary Sciences; and Fiona A. Harrison, Benjamin M. Rosen Professor of Physics.

"It is a privilege to honor these men and women for their extraordinary individual accomplishments," said Don Randel, chair of the academy's board of directors, of the 204 newly elected fellows and 16 foreign honorary members. "The knowledge and expertise of our members gives the academy a unique capacity—and responsibility—to provide practical policy solutions to the pressing challenges of the day. We look forward to engaging our new members in this work."

Brady works in the area of complex fluids and active matter that includes microstructural elements such as suspensions, colloidal dispersions, and self-propelling particles. Understanding these materials led Brady to develop a novel computational method called Stokesian dynamics. He won the 2012 Fluid Dynamics Prize from the American Physical Society and was elected to the National Academy of Engineering in 1999.

Most of Farley's research has focused on terrestrial geochemistry, but he is now increasingly interested in planetary science and especially exploration of the geochemistry, geology, and geomorphology of Mars. In his laboratory on the Caltech campus, Farley and his group measure noble gases such as helium and neon in rock and mineral samples. One major objective of this work is determining the ages and surface exposure history of Earth's geological features. Farley was recently involved in the first-ever experiments of this type carried out on the surface of Mars, via an instrument on board the Mars Science Laboratory's Curiosity rover. He has received the Day Medal of the Geological Society of America and the Macelwane Award of the American Geophysical Union, and was elected to the National Academy of Sciences in 2013.

Harrison specializes in observational and experimental high-energy astrophysics. She is the principal investigator for NASA's NuSTAR Explorer Mission and uses this satellite, along with other satellites and ground-based telescopes, to understand black holes, neutron stars, and supernova remnants. In her labs at Caltech, Harrison's group develops high-energy X-ray detectors and instrumentation for future space missions. She was elected to the American Physical Society in 2012 and won a NASA Outstanding Public Leadership Medal in 2013.

Also named to the academy this year is Katherine T. Faber, the Walter P. Murphy Professor of Materials Science and Engineering at Northwestern University, who will be joining the Caltech faculty on July 1 as the Simon Ramo Professor of Materials Science. Faber's research focuses on understanding fracture and toughening of brittle materials such as those used for high-temperature coatings for power generation applications. She also works on the fabrication of ceramic materials with controlled porosity. She is cofounder and codirector of the Northwestern University-Art Institute of Chicago Center for Scientific Studies in the Arts (NU-ACCESS), which employs advanced materials science techniques for conservation science. Faber is a Distinguished Life Member of the American Ceramic Society (2013), and became a National Science Foundation American Competitiveness and Innovation Fellow in 2010.

The total number of Caltech faculty named to the academy is now 97.

The academy was founded in 1780 by John Adams, James Bowdoin, John Hancock, and other scholar-patriots "to cultivate every art and science which may tend to advance the interest, honor, dignity, and happiness of a free, independent, and virtuous people." The academy has elected as fellows and foreign honorary members the finest minds and most influential leaders from each generation, including George Washington and Ben Franklin in the 18th century, Daniel Webster and Ralph Waldo Emerson in the 19th, and Albert Einstein and Winston Churchill in the 20th. The current membership includes more than 250 Nobel laureates and 60 Pulitzer Prize winners.

A full list of new members is available on the academy website at https://www.amacad.org/content/members/members.aspx.

The academy will welcome this year's new fellows and foreign honorary members at its annual induction ceremony at the academy's headquarters in Cambridge, Massachusetts, on October 11, 2014.

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On the Front Lines of Sustainability

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On the Front Lines of Sustainability
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The chemical processes used to make products ranging from pharmaceuticals to perfumes can have a harmful impact on the environment. However, Caltech chemist and Nobel laureate Robert Grubbs has spent several decades developing catalysts—compounds that speed up a chemical reaction—that can make the synthesis of these products more efficient and ecologically friendly, ultimately reducing their environmental footprint. Similarly, chemist Brian Stoltz is developing new strategies for the synthesis of compounds needed in the chemical, polymer, and pharmaceutical industries. His new processes rely upon oxygen and organometallic catalysts—greener alternatives to the toxic metals that are normally used to drive such reactions.

Switching from paper files to cloud-based data storage might seem like an obvious choice for sustainability, but can we further reduce the environmental impact of storing data? The theoretical work of engineer and computer scientist Adam Wierman suggests that with the right algorithms, we can. Today, data centers—the physical storage facilities Wierman calls the "SUVs of the Internet"—account for more than 1.5 percent of U.S. electricity usage. And as more data goes online, that number is expected to grow. Wierman's work helps engineers design algorithms that will reroute data, with preference to centers that use renewable energy sources like wind and solar.

Energy from the sun—although free and abundant—cannot easily be stored for use on dreary days or transported to cloudy regions. Caltech engineer and materials scientist Sossina Haile hopes to remove that barrier with a specific type of solar reactor she has developed. The reactor is lined with ceramic cerium oxide; when this lining is heated with concentrated sunlight it releases oxygen, priming it to remove oxygen from water molecules or carbon dioxide on cooling, thus creating hydrogen fuel or "syngas"—a precursor to liquid hydrocarbon fuels. This conversion of the sun's light into storable fuel could allow solar-derived power to be available day and night.

Caltech student participants in the Department of Energy's biennial Solar Decathlon competition set out to prove that keeping a house lit up, cooled down, and comfortable for living is possible—even while off the grid. The Techers teamed up with students at the Southern California Institute of Architecture to create CHIP and DALE, their entries in the 2011 and 2013 competitions, respectively. These functional and stylish homes, powered solely by the sun, were engineered with innovative components including a rainwater collection system and moving room modules that optimize heating and cooling efficiency. 

Although many of us take the nearest bathroom for granted, working toilets require resources and infrastructure that may not be available in many parts of the world. Inspired by the "Reinventing the Toilet Challenge" issued by the Bill and Melinda Gates Foundation, environmental scientist and engineer Michael Hoffmann and his team applied his research in hydrogen evolution and water treatment to reengineer the toilet. The Caltech team's design—which won the challenge in 2012—can serve hundreds of people each day, treat its own wastewater, and generate electricity, providing a sustainable and low-cost solution to sanitation and hygiene challenges in the developing world. Prototypes are being tested in India and China for use in urban and remote environments in the developing world.  

Geophysicist Mark Simons studies the mechanics of the Earth—furthering our understanding of what causes our planet to deform over time. His research often involves using satellite data to observe the movement associated with seismic and volcanic activity, but Simons is also interested in changes going on in the icy parts of Earth's surface, especially the dynamics of glaciers. By flying high above Iceland's ice caps, Simons and his colleagues can track the glaciers' melt-and-freeze response in relation to seasonal and long-term variations in temperature—and their potential response to climate change.

The production of industrial nitrogen fertilizer results in 130 million tons of ammonia annually—while also requiring high heat, high pressure, and lots of energy. However, in a process called nitrogen fixation, soil microorganisms that live near the roots of certain plants can produce a similar amount of ammonia each year. The bugs use catalysts called nitrogenases to convert nitrogen from the air into ammonia at room temperature and atmospheric pressure. By mimicking the behavior of these microorganisms, Jonas Peters and his colleagues synthesized an iron-based catalyst that allows for nitrogen fixation under much milder conditions. The catalyst could one day lead to more environmentally friendly methods of ammonia production.

Traditionally, the photovoltaic cells in solar panels have been expensive and have had limited efficiency—making them a hard sell in the consumer market. Engineer and applied physicist Harry Atwater's work suggests that there is a thinner and more efficient alternative. Atwater, who is also the director of the Resnick Sustainability Institute, uses thin layers of semiconductors to create photovoltaics that absorb sunlight as efficiently as thick solar cells but can be produced with higher efficiency than conventional cells.

The generation of chemical fuels from sunlight could completely change the way we power the planet. Researchers in the laboratory of Caltech chemist Nate Lewis are working to develop different components of a fuel-producing device that could do just that called a photoelectrochemical cell. The cell would consist of an upper layer that could absorb sunlight, carbon dioxide, and water vapor, a middle layer consisting of light absorbers and catalysts that can produce fuels, which are then released through the device's bottom layer. When such a device is created, the Joint Center for Artificial Photosynthesis, of which Lewis is the scientific director, aims to ease the transfer of these technologies to the private sector. 

Clean energy from the wind is a promising alternative to fossil fuels, but giant pinwheel-like wind turbines that are common on many wind farms can create dangerous obstacles for birds as well as being an unpleasant addition to a landscape's aesthetic. To combat this problem, Caltech engineer and fluid-mechanics expert John Dabiri is testing a new design for wind turbines, which looks a bit like a spinning eggbeater emerging from the ground. By placing these columnar vertical wind turbines in a careful arrangement—an arrangement inspired by the vortex of water created behind a swimming fish—his smaller vertical turbines create just as much energy as the "pinwheels" and on a much smaller land footprint.

In the early 1990s, Caltech bioengineer Frances Arnold pioneered "directed evolution"—a new method of engineering custom-built enzymes, or activity-boosting proteins. The technique allows mutations to develop in the enzyme's genetic code; these mutations can give the enzyme properties that don't occur in nature but are beneficial for human applications. The selectively enhanced enzymes help microbes turn plant waste and fast-growing grasses into fuels like isobutanol, which could sustainably replace more than half of U.S. oil imports, Arnold says. She's also exploring ways the technique could help factories to make pharmaceuticals and other products in much cleaner and safer ways.

The combined research efforts of Richard Flagan, John Seinfeld, Mitchio Okumura, and Paul Wennberg aim to improve our understanding of various aspects of climate change. Chemical engineer Flagan is pioneering ways to measure the number and sizes of particles in the air down to that of large molecules. Seinfeld studies where particles in the air come from, how they are produced by airborne chemical reactions, and the effect they have on the world's climate. Chemical physicist Okumura studies the chemical reactions that occur when sunlight encounters air pollution and results in smog. Wennberg, an atmospheric chemist, studies the natural and human processes that affect smog formation, the health of the ozone layer, as well as the lifetime of greenhouse gases. Wennberg and his colleagues join a legacy of Caltech researchers who have improved air quality through key discoveries about pollution.

In the past, researchers have discovered materials that can act as reaction catalysts, driving sunlight to split water into hydrogen fuel and an oxygen byproduct. However, these wonder materials are often expensive and in short supply. The research of chemist Harry Gray, who leads the National Science Foundation-funded Center for Chemical Innovation in Solar Fuels program, tests combinations of Earth-abundant metals to search for an inexpensive catalyst that boosts the water-splitting reaction with the sun. Gray also coleads an outreach project in which students in the classroom can participate in the race for solar fuels by testing thousands of materials and reporting their results to Caltech researchers.

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Although Earth Week has officially come to a close, Caltech's commitment to sustainability continues. In this feature, you will meet some of the researchers at Caltech whose work is contributing to a greener planet and to the long-term improvement of our global environment.

Research for a Greener Future

Today's Earth Week feature highlights three cross-disciplinary research centers where Caltech scientists and engineers collaborate on projects that will have a positive impact on energy, the environment, and Earth's sustainable future.

The Ronald and Maxine Linde Center for Global Environmental Science

The Ronald and Maxine Linde Center for Global Environmental Science brings together researchers from chemistry, engineering, geology, environmental science, and other disciplines, with the goal of understanding the global environment and developing solutions to complex environmental problems. Linde Center scientists investigate how Earth's climate and its atmosphere, oceans, and biosphere have varied in the past and how they may change in the future. They are working on solutions to vexing challenges in climate change prognosis and mitigation, and to improve air and water quality.

The Linde Center was established thanks to support from Caltech alumnus and trustee Ronald Linde and his wife, Maxine. Led by acting director Paul Wennberg, Caltech's R. Stanton Avery Professor of Atmospheric Chemistry and Environmental Science and Engineering, the center is housed in the Linde + Robinson Laboratory, which was constructed in 1932 as an astronomy lab. The building recently underwent extensive renovations, to become one of the nation's most energy-efficient laboratories and the first existing historic building to earn the LEED Platinum rating. In 2012, Linde + Robinson was honored with a 2012 Los Angeles Conservancy Preservation Award for the "exceptionally creative and sensitive approach" of the renovation. The project, the conservancy noted, "not only preserved the building's unique historic features, it found brilliant new uses for them—particularly the solar telescope, built as the centerpiece of the original building but functionally obsolete. Now it tracks the sun and uses the light it captures for both illumination and exploration."

Resnick Sustainability Institute

Caltech's Resnick Sustainability Institute was created to fund and foster innovative Caltech-based sustainability and energy-science research collaborations with the potential to develop renewable-energy technologies that may one day help solve our global energy and climate challenges. The mission of the institute, which was founded with a generous gift from Stewart and Lynda Resnick, spans research, education, and communications. Current projects include research into energy generation, such as advanced photovoltaics, photoelectrochemical solar fuels, cellulosic biofuels, and wind-energy system design; energy conversion work on batteries and fuel cells; and research into technologies for energy efficiency and management, such as fuel-efficient vehicles, green chemical synthesis, and thermoelectric materials, as well as advanced research on electrical grid control and distribution.

This year the Resnick Sustainability Institute debuted two new initiatives: the Resonate Awards, which honor breakthrough achievements in energy science and sustainability, and a prize postdoctoral fellowship program. The Resonate Award winners will be announced at the Fortune Brainstorm GREEN conference in May 2014, and the inaugural class of postdoctoral fellows will be announced this fall.

Led by Harry Atwater, Caltech's Howard Hughes Professor and professor of applied physics and materials science, the institute is collocated with the Joint Center for Artificial Photosynthesis (JCAP) in the recently renovated Jorgensen Laboratory, which has been awarded LEED Platinum certification. In the renovation, Caltech and its partners were able to reuse or recycle over 90 percent of the materials removed from the original facility, a computer science building. Jorgensen has high-efficiency lighting and HVAC systems, a "living roof" composed of evergreen and drought-tolerant grasses, and water-saving plumbing and landscaping, among other green features.

The Joint Center for Artificial Photosynthesis (JCAP)

JCAP, established in 2010 as a U.S. Department of Energy (DOE) Energy Innovation Hub, is the nation's largest research effort focused on artificial photosynthesis. Led by researchers from Caltech (JCAP South, housed at the Jorgensen Laboratory) and partner Lawrence Berkeley National Laboratory (JCAP North), the center aims to create a low-cost artificial generator that uses sunlight, carbon dioxide, and water to make fuel from the sun 10 times more efficiently than current living crops. Once a prototype generator is developed, it will be handed off to private-sector companies to launch a new solar-fuels industry. Such a transformative breakthrough would reduce our country's dependence on oil and enhance energy security.

JCAP researchers include Scientific Director Nathan S. Lewis, Caltech's George L. Argyros Professor and professor of chemistry; Jonas Peters, the Bren Professor of Chemistry; William A. Goddard, Charles and Mary Ferkel Professor of Chemistry, Materials Science, and Applied Physics; and Harry Atwater.

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Caltech and JPL Experts Discuss Climate Change

In today's installment of our Earth Week 2014 features, Caltech experts share their knowledge about climate change.

 

Caltech professor Jess Adkins, a geochemist and paleoclimatologist, offers insight into global warming in the video "Is There Hope for Planet Earth?" produced by Green Wish, a nonprofit organization that funds green initiatives at the local level. In the video, Adkins talks about the history of climate change, where we are today, and what we can do to mitigate its impact in the future.

 

On April 22—Earth Day—the Caltech Center for Teaching, Learning, & Outreach sponsored an "Ask A Scientist" panel on the Caltech campus to answer questions about climate change and earth sciences. Panel members included David Crisp, JPL senior research scientist and principal investigator of the NASA Earth System Science Pathfinder Orbiting Carbon Observatory mission; Joshua Fisher, JPL research scientist, Water and Carbon Cycles Group; science communicator and education specialist Laura Tenenbaum; and Caltech alumnus Julius Su (BS '98 and '99, PhD '07), cofounder of Su-Kam Intelligent Education Systems (SKIES). Su used the SKIES iPad app, an online learning and information crowdsourcing tool, to relay online and audience questions to the panelists. The video is a recording of the live event.

 

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Monday, May 5, 2014
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Experiences from two years of MOOCs at Caltech: A WEST Public Seminar

Friday, April 11, 2014
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Spring Ombudsperson Training

Wednesday, April 16, 2014
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New Method Could Improve Ultrasound Imaging

Caltech chemical engineer shows hidden potential of gas vesicles

One day while casually reading a review article, Caltech chemical engineer Mikhail Shapiro came across a mention of gas vesicles—tiny gas-filled structures used by some photosynthetic microorganisms to control buoyancy. It was a light-bulb moment. Shapiro is always on the lookout for new ways to enhance imaging techniques such as ultrasound or MRI, and the natural nanostructures seemed to be just the ticket to improve ultrasound imaging agents.

Now Shapiro and his colleagues from UC Berkeley and the University of Toronto have shown that these gas vesicles, isolated from bacteria and from archaea (a separate lineage of single-celled organisms), can indeed be used for ultrasound imaging. The vesicles could one day help track and reveal the growth, migration, and activity of a variety of cell types—from neurons to tumor cells—using noninvasive ultrasound, one of the most widely used imaging modalities in biomedicine.

A paper describing the work appears as an advance online publication in the journal Nature Nanotechnology

"People have struggled to make synthetic nanoscale imaging agents for ultrasound for many years," says Shapiro. "To me, it's quite amazing that we can borrow something that nature has evolved for a completely different purpose and use it for in vivo ultrasound imaging. It shows just how much nature has to offer us as engineers."

Ultrasound transmitters use sound waves to image biological tissue. When the emitted waves encounter something of a different density or stiffness, such as bone, some of the sound bounces back to the transducer. By measuring how long that round-trip journey takes, the system can determine how deep the object is and build up a picture of internal anatomy.

But what if you want to image something other than anatomy? Maybe you are interested in blood flow and want to see whether there are any signs of atherosclerosis, for example, in blood vessels. To make ultrasound useful in such cases, you need to introduce an imaging label that has a different density or stiffness from bodily tissue. Currently, people use microbubbles—small synthetic bubbles of gas with a lipid or protein shell—to image the vasculature. These microbubbles are less dense and more elastic than the water-based tissues of the body. As a result, they resonate and scatter sound waves, allowing ultrasound to visualize the location of the microbubbles.

Microbubbles work just fine, unless you want to image something outside the bloodstream. Because of their diameter—small, but still on the order of microns—the bubbles are too large to get out of the bloodstream and into surrounding tissue. And as Shapiro says, "Many interesting targets—such as specific types of tumors, immune cells, stem cells, or neurons—are outside the bloodstream."

A number of research teams have tried, without success, to make microbubbles smaller. There is a fundamental physical reason for their failure: bubbles are held together by surface tension. As you make them smaller, the surface tension builds, and the pressure within the bubble becomes too high in comparison to the pressure outside. That amounts to an unstable bubble that is likely to lose its gas to its surroundings.

The gas vesicles Shapiro's team worked with are at least an order of magnitude smaller than microbubbles—measuring just tens to hundreds of nanometers in diameter. And even though they look like bubbles, gas vesicles behave quite differently. Unlike bubbles, the vesicles do not trap gas molecules but allow them to pass freely in and out. Instead, they exclude water from their interior by having a hydrophobic inner surface. This results in a fundamentally stable nanoscale configuration.

 "As soon as I learned about them, I knew we had to try them," Shapiro says. 

The researchers first isolated gas vesicles from the bacterium Anabaena flos-aquae (Ana) and the archaeon Halobacterium NRC-1 (Halo), put them in an agarose gel, and used a home-built ultrasound system to image them. Vesicles from both sources produced clear ultrasound signals. Next, they injected the gas vesicles into mice and were able to follow the vesicles from the initial injection site to the liver, where blood flows to be detoxified. Shapiro and his colleagues were also able to easily attach biomolecules to the surface of the gas vesicles, suggesting that the gas vesicles could be used to label targets outside the bloodstream.

Shapiro's long-term goal is to take advantage of the fact that the gas vesicles are genetically encoded by engineering their properties at the DNA level and ultimately introducing the genes into mammalian cells to produce the structures themselves. For example, he would like to genetically label stem cells and use ultrasound to watch as they migrate to specific locations within the body and differentiate into tissues.

"Now that we have our hands on the genes that encode these gas vesicles, we can engineer them to optimize their properties, to see how far they can go," Shapiro says.

In their work, the researchers found differences in the gas vesicles produced by Ana and Halo. These variations could provide insight into how the vesicle design could be optimized for other purposes. For example, unlike the Ana vesicles, the Halo vesicles produced harmonic signals—meaning that they caused the original ultrasound wave to come back, as well as waves with doubled and tripled frequencies. Harmonics can be helpful in imaging because most tissue does not produce such signals; so when they show up, researchers know that they are more likely to be coming from the imaging agent than from the tissue.

Also, the gas vesicles from the two species collapsed, and thereby became invisible to ultrasound, with the application of different levels of pressure. Halo gas vesicles, which evolved in unpressurized cells, collapsed more easily than the vesicles from Ana, which maintain a pressurized cytoplasm. The researchers used this fact to distinguish the two different populations in a mixed sample. By applying a pressure pulse sufficient to collapse only the Halo vesicles, they were able to identify the remaining gas vesicles as having come from Ana.

Shapiro notes that there is a substantial difference between the critical collapse pressures of Halo and Ana. "There's quite a good possibility that, as we start to genetically engineer these nanostructures, we would be able to make new ones with intermediate collapse pressures," he says. "That would allow you to image a greater number of cells at the same time. This sort of multiplexing is done all the time in fluorescent imaging, and now we want to do it with ultrasound."

Along with Shapiro, coauthors on the paper, "Biogenic gas nanostructures as ultrasonic molecular reporters," are Patrick Goodwill, Arkosnato Neogy, David Schaffer, and Steven Conolly of UC Berkeley, and Melissa Yin and F. Stuart Foster of the University of Toronto. The work was supported by funding from the Miller Research Institute, the Burroughs Wellcome Fund's Career Award at the Scientific Interface, the California Institute of Regenerative Medicine, the National Institutes of Health, the Canadian Institutes of Health Research, and the Terry Fox Foundation.

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Kimm Fesenmaier
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Watching the Brain Do Its Thing: An Interview with Mikhail Shapiro

To a large extent, the brain remains a black box. Taking it out of its case inside the skull and examining it—as in an autopsy—reveals some things, but not how the brain works in a living, functioning being. Assistant Professor of Chemical Engineering Mikhail Shapiro is determined to reveal the mysteries of the brain in situ, in living beings, right down to the cellular level.

Shapiro comes to Caltech from UC Berkeley, where he launched his independent research career as a Miller Fellow. Prior to that, Shapiro was a postdoctoral fellow at the University of Chicago. He received his PhD from the Massachusetts Institute of Technology. Shapiro recently sat down to discuss his research and his adjustment to his new life at Caltech.

What are you most excited about in coming to Caltech?

I'm excited for the opportunity to collaborate with the amazing faculty and students we have here across the disciplines. My first three PhD students all come from different programs, and I already have a collaboration with a colleague in electrical engineering. I can't imagine this happening so quickly and naturally anywhere else in the world.

What is the main focus of your research?

The goal of our research is to develop ways to study biological systems at the cellular level in living, breathing organisms. To do that we need ways to image and control specific molecular functions in tissues noninvasively.

Great advances have been made with dyes and fluorescent proteins to help scientists see what's happening inside living cells, but these techniques don't allow us to penetrate very deeply into larger tissues. So what we want to do is create the equivalents of dyes and fluorescent proteins for technologies like ultrasound and magnetic resonance imaging (MRI) so that we can see and label very specific things deep inside the body, and particularly in the brain.

For example, we are interested in how neural stem cells in the brain—which are regenerated even in adults—develop into different types of brain cells. What kinds of genes do they turn on and off, as they become a neuron or a glial cell in different parts of the brain? We are designing molecular reporters that will allow us to use MRI or ultrasound to monitor these cells as they migrate, express genes, and integrate into functional neural circuits.

How do you get these "molecular reporters" into the body?

The vast majority of the things we're working on are genetically encodable, which means that we can take the relevant genes, put them into a vector—for example, a nontoxic virus—and deliver them to specific cells. So not only would we be able to target a particular region of the brain, but we would be able to target specific cell types.

Will the technologies you're developing be useful in exploring other systems in the body?

Yes. Our main raison d'etre is to develop ways to probe the nervous system, but the technologies we develop could be used in a variety of biological contexts and in synthetic biology. In addition, we are fascinated by the basic science involved with connecting various forms of energy—magnetic fields, sound waves, temperature—with biological molecules and cells. This interface is relatively unexplored, and we hope to contribute to its fundamental understanding.

What do you like about Caltech?

I've always thought of Caltech as a scientific paradise. The density of high-quality research here is second to none. It's an environment that encourages the pursuit of big, bold ideas across disciplines. That's why I went into academia, so this is the place to be.

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Caltech Appoints Diana Jergovic to Newly Created Position of Vice President for Strategy Implementation

Caltech has named Diana Jergovic as its vice president for strategy implementation. In the newly created position, Jergovic will collaborate closely with the president and provost, and with the division chairs, faculty, and senior leadership on campus and at the Jet Propulsion Laboratory, to execute and integrate Caltech's strategic initiatives and projects and ensure that they complement and support the overall education and research missions of the campus and JPL. This appointment returns the number of vice presidents at the Institute to six.

"Supporting the faculty is Caltech's highest priority," says Edward Stolper, provost and interim president, "and as we pursue complex interdisciplinary and institutional initiatives, we do so with the expectation that they will evolve over a long time horizon. The VP for strategy implementation will help the Institute ensure long-term success for our most important new activities."

In her present role as associate provost for academic and budgetary initiatives at the University of Chicago, Jergovic serves as a liaison between the Office of the Provost and the other academic and administrative offices on campus, and advances campus-wide strategic initiatives. She engages in efforts spanning every university function, including development, major construction, and budgeting, as well as with faculty governance and stewardship matters. Jergovic also serves as chief of staff to University of Chicago provost Thomas F. Rosenbaum, Caltech's president-elect.

"In order to continue Caltech's leadership role and to define new areas of eminence, we will inevitably have to forge new partnerships and collaborations—some internal, some external, some both," Rosenbaum says. "The VP for strategy implementation is intended to provide support for the faculty and faculty leaders in realizing their goals for the most ambitious projects and collaborations, implementing ideas and helping create the structures that make them possible. I was looking for a person who had experience in delivering large-scale projects, understood deeply the culture of a top-tier research university, and could think creatively about a national treasure like JPL."

"My career has evolved in an environment where faculty governance is paramount," Jergovic says. "Over the years, I have cultivated a collaborative approach working alongside a very dedicated faculty leadership. My hope is to bring this experience to Caltech and to integrate it into the existing leadership team in a manner that simultaneously leverages my strengths and allows us together to ensure that the Institute continues to flourish, to retain its position as the world's leading research university, and to retain its recognition as such."

Prior to her position as associate provost, Jergovic was the University of Chicago's assistant vice president for research and education, responsible for the financial management and oversight of all administrative aspects of the Office of the Vice President for Research and Argonne National Laboratory. She engaged in research-related programmatic planning with a special emphasis on the interface between the university and Argonne National Laboratory. This ranged from the development of the university's Science and Technology Outreach and Mentoring Program (STOMP), a weekly outreach program administered by university faculty, staff, and students in low-income neighborhood schools on the South Side of Chicago, to extensive responsibilities with the university's successful bid to retain management of Argonne National Laboratory.

From 1994 to 2001, Jergovic was a research scientist with the university-affiliated National Opinion Research Center (NORC) and, in 2001, served as project director for NORC's Florida Ballot Project, an initiative that examined, classified, and created an archive of the markings on Florida's 175,000 uncertified ballots from its contested 2000 presidential election.

Jergovic earned a BS in psychology and an MA and PhD in developmental psychology, all from Loyola University Chicago, and an MBA from the Booth School of Business at the University of Chicago.

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