Improving The View Through Tissues and Organs

This summer, several undergraduate students at Caltech had the opportunity to help optimize a promising technique that can make tissues and organs—even entire organisms—transparent for study. As part of the Summer Undergraduate Research Fellowship (SURF) program, these students worked in the lab of Assistant Professor of Biology Viviana Gradinaru, where researchers are developing such so-called clearing techniques that make it possible to peer straight through normally opaque tissues rather than seeing them only as thinly sectioned slices that have been pieced back together.

Sensors to Simplify Diabetes Management

Caltech students use their Summer Undergraduate Research Fellowship opportunities to advance the idea of painless diabetes management.

Orchestrating the Healing Process in a Damaged Cornea

SURF fellow Jacqueline Masehi-Lano has experimented with various growth factors that might inhibit the formation of scar tissue and promote orderly wound healing.

A New Way to Prevent the Spread of Devastating Diseases

Researchers around the country are adopting a technique developed in the Caltech lab of Nobel Laureate David Baltimore to try to guard against infection. The method, called VIP, was originally designed to trigger an immune response to HIV, and because of its success with HIV is now being studied, in mice, for protection against influenza, malaria, hepatitis C, and tuberculosis.

Sensing Neuronal Activity With Light

A technique developed by Caltech researchers uses a genetic tool and light to view and map neuronal circuits.

Emotions in the Brain: An Interview with David Anderson

We recently spoke to David Anderson, Caltech's Seymour Benzer Professor of Biology, about this work, his goals, and how the interdisciplinary collaborations he is building at Caltech are helping to spur a revolution in neuroscience.

Slimy Fish and the Origins of Brain Development

Work at Caltech's unique lamprey facility provides important insights about the evolutionary history of vertebrate brain development.

Tipping the Balance of Behavior

Caltech researchers have discovered a seesaw-like circuit in the brain that controls the choice between social and repetitive self-oriented behaviors in mice.

Seeing Protein Synthesis in the Field

Caltech researchers have developed a novel way to visualize proteins generated by microorganisms in their natural environment—including the murky waters of Caltech's lily pond.

Biology Made Simpler With "Clear" Tissues

Thanks to new techniques developed at Caltech, scientists can now see through tissues, organs, and even an entire body, offering new insights into the cell-by-cell makeup of organisms—and the promise of novel diagnostic medical applications.

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