An Eye for Science: In the Lab of Markus Meister

Take one look around Markus Meister's new lab and office space on the top floor of the Beckman Behavioral Biology building, and you can tell that he has an eye for detail. Curving, luminescent walls change color every few seconds, wrapping around lab space and giving a warm glow to the open, airy offices that line the east wall. A giant picture of neurons serves as wallpaper, and a column is wrapped in an image from the inside of a retina. And while he may have picked up some tips from his architect wife to help direct the design of his lab, Meister is the true visionary—a biologist studying the details of the eye.

A Fresh Look at Psychiatric Drugs

Drugs for psychiatric disorders such as depression and schizophrenia often require weeks to take full effect. "What takes so long?" has formed one of psychiatry's most stubborn mysteries. Now a fresh look at previous research on quite a different drug—nicotine—is providing answers. The new ideas may point the way toward new generations of psychiatric drugs that work faster and better.

Tuesday, April 9, 2013
Avery Library

Spring Teaching Assistant Orientation

Developmental Bait and Switch

During the early developmental stages of vertebrates—animals that have a backbone and spinal column, including humans—cells undergo extensive rearrangements, and some cells migrate over large distances to populate particular areas and assume novel roles as differentiated cell types. Understanding how and when such cells switch their purpose in an embryo is an important and complex goal for developmental biologists. A recent study, led by researchers at the California Institute of Technology (Caltech), provides new clues about this process—at least in the case of neural crest cells, which give rise to most of the peripheral nervous system, to pigment cells, and to large portions of the facial skeleton.

Progress for Paraplegics

Caltech engineers, who last year helped enable a paraplegic man to stand and move his legs voluntarily, have developed a new method to automate the system, which provides epidural electrical stimulation to people with spinal-cord injuries. This advancement could make the technology widely available to rehab clinics and thousands of patients worldwide. It would also reduce the system's training time and costs for hospitals and clinics and make it easier for patients to continue their rehabilitation at home.

Two Faculty Members Named Packard Fellows

Two Caltech faculty members have been awarded Packard Fellowships for Science and Engineering. Biologist Alexei Aravin and astronomer John Johnson each were awarded $875,000, to be distributed over five years.

"I'm very excited about this fellowship," says Aravin, an assistant professor of biology. "It will allow my lab to pursue new, ambitious goals that are difficult to fund using traditional sources."

Wordy Worms

Lurking in the crevices of our planet are millions and millions of microscopic worms. They live in soil, plants, water, ice, wildlife, and sometimes even humans. In fact, nematodes—also known as roundworms—are among the most abundant and diverse animals on Earth, where they play a variety of roles.

Traveling with Purpose

Pamela Bjorkman has been studying HIV at Caltech since 2005. In the lab, she has made significant gains in the fight against the virus, developing antibodies that neutralize most strains. But years spent at the bench were beginning to make her feel disconnected from the possible impact of her work. So this summer she visited India, spending time with HIV-positive women and others who are at risk.

Caltech Again Named World's Top University in <i>Times Higher Education</i> Global Ranking

PASADENA, Calif.—The California Institute of Technology (Caltech) has been rated the world's number one university in the 2012–2013 Times Higher Education global ranking of the top 200 universities.

Oxford University, Stanford University, Harvard University, and MIT round out the top five.

Caltech Biologist Named MacArthur Fellow

Sarkis Mazmanian, a microbiology expert at the California Institute of Technology (Caltech) whose studies of human gut bacteria have revealed new insights into how these microbes can be beneficial, was named a MacArthur Fellow and awarded a five-year, $500,000 “no strings attached” grant.


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