The human body is full of tiny microorganisms, and the GI tract is home to the largest concentration and highest diversity of bacterial species. But how do these organisms persist and thrive in a system that is constantly in flux due to foods and fluids moving through it? A team led by Caltech biologist Sarkis Mazmanian believes it has found the answer, at least in one common group of bacteria: a set of genes that promotes stable microbial colonization of the gut.
The Rosen Center supports bioengineering research through the funding of fellows and faculty from many disciplines, including applied physics, chemical engineering, synthetic biology, and computer science.
A team of researchers led by newly arrived Caltech biologist Mitchell Guttman and Kathrin Plath of UCLA, has figured out how some RNA molecules take advantage of their position within the 3-D structure of genomic material to home in on targets.