Like a commuter trying to get to work during rush hour, a growing axon must thread its way through a throng of other axons that are headed in many different directions in the developing brain. Axons are the wire-like extensions of nerve cells that carry electrical signals from one place to another in the brain, and during development they must navigate across long distances (many centimeters) to reach their correct address within the brain. If the axon gets lost, brain circuits cannot form normally and, like the commuter showing up at the wrong office, the axon may not be able to do its job. So how do axons find their way? A report published in the July 24th issue of the journal Science by Drs. Susan Catalano and Carla Shatz of the University of California at Berkeley sheds light on how axons home in on their correct targets. New Study Shows How Axons Find Their Way Home July 1998 98