Submitted by lorio on Wed, 2010-04-14 07:00
A typical human cell contains hundreds of mitochondria—energy-producing organelles—that continually fuse and divide. Relatively little is known, however, about why mitochondria undergo this behavior. Now, scientists at the Caltech have taken steps toward a fuller understanding of this process by revealing just what happens to the organelle, its DNA (mtDNA), and its energy-producing ability when mitochondrial fusion fails.
Submitted by lorio on Fri, 2010-04-02 07:00
Scientists from the Caltech have provided the first-ever glimpse of the structure of a key protein—gp120—found on the surface of a specific subgroup of the human immunodeficiency virus, HIV-1. In addition, they demonstrated that a particular antibody to gp120 makes contact not only with the protein, but with the CD4 receptor that gp120 uses to gain entrance into the body's T cells.
Submitted by Anonymous (not verified) on Sun, 2010-03-21 18:00
A Caltech-led team of researchers and clinicians has published the first proof that a targeted nanoparticle—used as an experimental therapeutic and injected directly into a patient's bloodstream—can traffic into tumors, deliver double-stranded small interfering RNAs, and turn off an important cancer gene using a mechanism known as RNA interference. Moreover, the team demonstrated that this new type of therapy can make its way to human tumors in a dose-dependent fashion.
Submitted by ksvitil on Tue, 2010-03-16 07:00
Researchers at Caltech and the University of California, San Diego have discovered that injecting a simple hormone into leeches creates a novel way to study how hormones and the nervous system work together to produce species-specific reproductive behavior. A paper describing the work appears in the March 11 online edition of the journal Current Biology.
Submitted by Anonymous (not verified) on Wed, 2010-02-24 08:00
Research in genomic sciences, astronomy, seismology, and neuroeconomics are some of the many projects being funded at the California Institute of Technology (Caltech) by the American Recovery and Reinvestment Act (ARRA).
Submitted by ksvitil on Sun, 2010-02-14 18:01
Researchers at Caltech have obtained the first recordings of brain-cell activity in an actively flying fruit fly. The work—by Michael Dickinson, the Esther M. and Abe M. Zarem Professor of Bioengineering, with postdoctoral scholars Gaby Maimon and Andrew Straw—suggests that at least part of the brain of the fruit fly (Drosophila melanogaster) "is in a different and more sensitive state during flight than when the fly is quiescent," Dickinson says.
Submitted by lorio on Thu, 2009-12-17 08:00
For decades, science texts have told a simple and straightforward story about a particular protein—a transcription factor—that helps the embryo of the fruit fly pattern tissues in a manner that depends on the levels of this factor within individual cells. Now Angelike Stathopoulos and her Caltech colleagues have called that paradigm into question.
Submitted by Anonymous (not verified) on Wed, 2009-12-16 08:00
Caltech and UCLA have announced the establishment of the Joint Center for Translational Medicine (JCTM), which will advance experimental research into clinical applications, including the diagnosis and therapy of diseases such as cancer.
Submitted by lorio on Sun, 2009-12-06 18:00
Have you ever found yourself struggling to get your order taken at a crowded bar or lunch counter, only to walk away in disgust as more aggressive customers elbow their way to the front? It turns out that flies do much the same thing, according to biologists from Caltech.
Submitted by lorio on Wed, 2009-12-02 18:00
Researchers from Caltech have been able to view in detail, and for the first time, the previously mysterious process by which long chains of a protein called ubiquitin are added by enzymes called ubiquitin ligases to proteins that control the cell cycle. Ubiquitin chains tag target proteins for destruction by protein-degrading complexes in the cell. Their findings, and the innovative process by which they were obtained, are described in this week's issue of Nature.