Biologists Deliver Neutralizing Antibodies that Protect Against HIV Infection in Mice

Over the past year, researchers at Caltech, and around the world, have been studying a group of potent antibodies that have the ability to neutralize HIV in the lab; their hope is that they may learn how to create a vaccine that makes antibodies with similar properties. Now, biologists at Caltech led by Nobel Laureate David Baltimore have taken one step closer to that goal: they have developed a way to deliver these antibodies to mice and, in so doing, have effectively protected them from HIV infection.

 

Caltech Scientists Point to Link between Missing Synapse Protein and Abnormal Behaviors

Although many mental illnesses are uniquely human, animals sometimes exhibit abnormal behaviors similar to those seen in humans with psychological disorders. Such behaviors are called endophenotypes. Now, Caltech researchers have found that mice lacking a gene that encodes a particular protein found in the synapses of the brain display a number of endophenotypes associated with schizophrenia and autism spectrum disorders.

Caltech Researchers Find Pulsating Response to Stress in Bacteria

Turning on the heater is a reasonable response to a cold environment: switch to a toastier state until it warms up outside. Biologists have long thought cells would respond to their environment in a similar way. But now researchers at Caltech are finding that cells can respond using a new kind of pulsating mechanism. The principles behind this process are surprisingly simple, the researchers say, and could drive other cellular processes, revealing more about how the cells—and ultimately life—work.

Switching Senses

Many meat-eating animals have unique ways of hunting down a meal using their senses. To find a tasty treat, bats use echolocation, snakes rely on infrared vision, and owls take advantage of the concave feathers on their faces, the better to help them hear possible prey. Leeches have not just one but two distinct ways of detecting dinner, and, according to new findings from biologists at Caltech, their preferred method changes as they age.

 

 

Building Better HIV Antibodies

Using highly potent antibodies isolated from HIV-positive people, researchers have recently begun to identify ways to broadly neutralize the many possible subtypes of HIV. Now, a team led by biologists at Caltech has built upon one of these naturally occurring antibodies to create a stronger version they believe is a better candidate for clinical applications. 

 

Caltech Professors Mark E. Davis and David A. Tirrell Elected to the Institute of Medicine

Mark E. Davis and David A. Tirrell of Caltech have been elected to the Institute of Medicine, an honor that is considered among the highest in the fields of health and medicine. Both Davis and Tirrell are already members of the National Academy of Sciences and the National Academy of Engineering, making them two of only 13 living individuals who have been elected to all three branches of the National Academies.

Caltech Named World's Top University in New Times Higher Education Global Ranking

Caltech has been rated the world's number one university in the 2011–2012 Times Higher Education global ranking of the top 200 universities, displacing Harvard University from the top spot for the first time in the survey's eight-year history. 

Caltech Engineers Build Smart Petri Dish

The cameras in our cell phones have dramatically changed the way we share the special moments in our lives, making photographs instantly available to friends and family. Now, the imaging sensor chips that form the heart of these built-in cameras are helping engineers at the California Institute of Technology (Caltech) transform the way cell cultures are imaged by serving as the platform for a "smart" petri dish. 

Caltech Neuroscientists Record Novel Responses to Faces from Single Neurons in Humans

Responding to faces is a critical tool for social interactions between humans. Without the ability to read faces and their expressions, it would be hard to tell friends from strangers upon first glance, let alone a sad person from a happy one. Now, neuroscientists from Caltech, with the help of collaborators at Huntington Memorial Hospital in Pasadena and Cedars-Sinai Medical Center in Los Angeles, have discovered a novel response to human faces by looking at recordings from brain cells in neurosurgical patients.

Four Caltech Researchers Given NIH Director's Awards

Four members of the California Institute of Technology (Caltech) faculty—William Clemons Jr., assistant professor of biochemistry; Thanos Siapas, professor of computation and neural systems; Long Cai, assistant professor of chemistry; and Lea Goentoro, assistant professor of biology—have been named among the researchers being given National Institutes of Health (NIH) Director's Awards.

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