Modeling the Genes for Development

As an animal develops from an embryo, its cells take diverse paths, eventually forming different body parts—muscles, bones, heart. In order for each cell to know what to do during development, it follows a genetic blueprint, which consists of complex webs of interacting genes called gene regulatory networks. Now, for the first time, biologists at Caltech have built a computational model of one of these networks.

Caltech Researchers Find Evidence of Link between Immune Irregularities and Autism

A new Caltech study suggests that specific changes in an overactive immune system can contribute to autism-like behaviors in mice, and that in some cases, this activation can be related to what a developing fetus experiences in the womb.

Caltech Receives Gift from Sackler Foundation to Advance Biomedical Science Research

Caltech and UCLA have launched highly productive collaborations in cancer research and other areas of biomedicine in recent years, frequently through the Caltech lab of Nobel Laureate and President Emeritus David Baltimore. Now, an endowment established by the Raymond and Beverly Sackler Foundation will strengthen the Caltech-UCLA partnership and advance the Baltimore lab’s interdisciplinary research into areas where mathematics and engineering converge with biology.

 

Caltech Biologist Stephen Mayo Named Inaugural Bowes Division Chair

Stephen L. Mayo, chair of the Division of Biology and Bren Professor of Biology and Chemistry at Caltech, has been named the William K. Bowes Jr. Foundation Division Chair. The William K. Bowes, Jr. Foundation, based in San Francisco, endowed the new division leadership chair with a $5 million gift, supplemented by an additional $2.5 million provided by the Gordon and Betty Moore Matching Program.

The Physics of Going Viral

Caltech researchers have been able, for the first time, to watch viruses infecting individual bacteria by transferring their DNA, and to measure the rate at which that transfer occurs. Shedding light on the early stages of infection by this type of virus—a bacteriophage—the scientists have determined that it is the cells targeted for infection, rather than the amount of genetic material within the viruses themselves, that dictate how quickly the bacteriophage's DNA is transferred.

Sarkis Mazmanian Discusses Benevolent Bacteria in Scientific American

There are trillions of bacteria living in our bodies, making up complex communities of microbes regulating processes like digestion and immunity. For Caltech biologist Sarkis Mazmanian, they also make up the focus of his research: understanding how the "good" bacteria promote human health. Featured in the cover story for the June issue of Scientific American, he makes a case for devoting more attention to the helpful bugs after years of scientific dedication to pathogens. 

Decoding Worm Lingo

All animals seem to have ways of exchanging information—monkeys vocalize complex messages, ants create scent trails to food, and fireflies light up their bellies to attract mates. Yet, despite the fact that nematodes, or roundworms, are among the most abundant animals on the planet, little is known about the way they network. Now, research led by California Institute of Technology (Caltech) biologists has shown that a wide range of nematodes communicate using a recently discovered class of chemical cues. 

Determining a Stem Cell's Fate

What happens to a stem cell at the molecular level that causes it to become one type of cell rather than another? In studies that mark a major step forward in our understanding of stem cells' fates, a team of Caltech researchers has traced the stepwise developmental process that ensures certain stem cells will become T cells—cells of the immune system that help destroy invading pathogens. 

Alexander Varshavsky Awarded Otto Warburg Medal

Alexander Varshavsky, Caltech's Howard and Gwen Laurie Smits Professor of Cell Biology, has been awarded the Otto Warburg Medal of the German Society for Biochemistry and Molecular Biology (GBM). The medal is considered to be the highest German award for biochemists and molecular biologists.

 

Do You Hear What I Hear?

In both animals and humans, vocal signals used for communication contain a wide array of different sounds that are determined by the vibrational frequencies of vocal cords. Knowing how the brain sorts out these different frequencies—which are called frequency-modulated (FM) sweeps—is believed to be essential to understanding many hearing-related behaviors, like speech. Now, a pair of biologists at Caltech has identified how and where the brain processes this type of sound signal.

Pages

Subscribe to RSS - BBE