A Caltech-led team of researchers and clinicians has published the first proof that a targeted nanoparticle—used as an experimental therapeutic and injected directly into a patient's bloodstream—can traffic into tumors, deliver double-stranded small interfering RNAs, and turn off an important cancer gene using a mechanism known as RNA interference. Moreover, the team demonstrated that this new type of therapy can make its way to human tumors in a dose-dependent fashion.
These boots are made for walking . . . and for powering up your cell phone? It could happen, say a team of Princeton and Caltech scientists. In a recent paper in the journal Nano Letters, they report that they have developed an innovative rubber chip that has the ability to harvest energy from motions such as walking, running, and breathing and convert it into a power source.
Caltech researchers have developed a way to make some notoriously brittle materials ductile—yet stronger than ever—simply by reducing their size. The work could eventually lead to innovative, superstrong, yet light and damage-tolerant materials. These materials could be used as components in structural applications, such as in lightweight aerospace vehicles that last longer under extreme environmental conditions and in naval vessels that are resistant to corrosion and wear.
Researchers at the Caltech have proposed a new paradigm that should allow scientists to observe quantum behavior in small mechanical systems. Their ideas, described in the early online issue of the Proceedings of the National Academy of Sciences, offer a new means of addressing one of the most fascinating issues in quantum mechanics: the nature of quantum superposition and entanglement in progressively larger and more complex systems.
Techniques recently invented by researchers at the California Institute of Technology (Caltech)—which allow the real-time, real-space visualization of fleeting changes in the structure of nanoscale matter—have been used to image the evanescent electrical fields produced by the interaction of electrons and photons, and to track changes in atomic-scale structures.
In work that someday may lead to the development of novel types of nanoscale electronic devices, an interdisciplinary team of researchers at the California Institute of Technology (Caltech) has combined DNA's talent for self-assembly with the remarkable electronic properties of carbon nanotubes, thereby suggesting a solution to the long-standing problem of organizing carbon nanotubes into nanoscale electronic circuits.
Researchers at the California Institute of Technology (Caltech) have created a nanoscale crystal device that, for the first time, allows scientists to confine both light and sound vibrations in the same tiny space. "This is a whole new concept," notes Oskar Painter, associate professor of applied physics at Caltech. Painter is the principal investigator on the paper describing the work, which was published in the online edition of the journal Nature.
Caltech scientists have uncovered the physical mechanism by which arrays of nanoscale pillars can be grown on polymer films with very high precision, in potentially limitless patterns. This nanofluidic process—described in a recent article in Physical Review Letters—could someday replace the conventional lithographic patterning techniques now used to build 3-D nano- and microscale structures for use in optical, photonic, and biofluidic devices.
Scientists at the Caltech and IBM's Almaden Research Center have developed a new technique to orient and position self-assembled DNA shapes and patterns--or "DNA origami"--on surfaces that are compatible with today's semiconductor manufacturing equipment. These precisely positioned DNA nanostructures, each no more than one one-thousandth the width of a human hair, can serve as scaffolds or miniature circuit boards for the precise assembly of computer-chip components.