Medical Science News

05/21/2013 09:58:03
Katie Neith
When infections occur in the body, stem cells in the blood often jump into action by multiplying and differentiating into mature immune cells that can fight off illness. But repeated infections and inflammation can deplete these cell populations, potentially leading to the development of serious blood conditions such as cancer. Now, a team of researchers led by biologists at the California Institute of Technology (Caltech) has found that, in mouse models, the molecule microRNA-146a (miR-146a) acts as a critical regulator and protector of blood-forming stem cells (called hematopoietic stem cells, or HSCs) during chronic inflammation, suggesting that a deficiency of miR-146a may be one important cause of blood cancers and bone marrow failure.
02/10/2011 00:00:00
Lori Oliwenstein

Where does violence live in the brain? And where, precisely, does it lay down its biological roots? With the help of a new genetic tool that uses light to turn nerve cells on and off, a team led by researchers at the California Institute of Technology (Caltech) has tracked down the specific location of the neurons that elicit attack behaviors in mice, and defined the relationship of those cells to the brain circuits that play a key role in mating behaviors.

08/18/2010 23:00:00
Lori Oliwenstein

Two scientists from Caltech have been recognized by the National Institutes of Health for their innovative and high-impact biomedical research programs. Michael Roukes, professor of physics, applied physics, and bioengineering, and co-director of the Kavli Nanoscience Institute, and Pamela Bjorkman, Caltech's Max Delbrück Professor of Biology and a Howard Hughes Medical Institute investigator, now join the 81 Pioneers who have been selected since the program's inception in 2004.

 

08/04/2010 17:00:00
Kathy Svitil

One key to fighting diseases such as leukemia and anemia is gaining an understanding of the genes and molecules that control the function of hematopoietic—or blood—stem cells, which provide the body with a constant supply of red and white blood cells and platelets. Biologists at Caltech have taken a large step toward that end, with the discovery of a novel group of molecules that are found in high concentrations within hematopoietic stem cells and appear to regulate their production.

08/02/2010 23:00:00
Kathy Svitil

Our belief as to whether we will likely succeed or fail at a given task—and the consequences of winning or losing—directly affects the levels of neural effort put forth in movement-planning circuits in the human cortex, according to a new brain-imaging study by Caltech neuroscientists. 

07/19/2010 11:00:00
Kathy Svitil

Biologists at Caltech have demonstrated a connection between multiple sclerosis (MS)—an autoimmune disorder that affects the brain and spinal cord—and gut bacteria.

07/02/2010 02:00:00
Kathy Svitil

When does a cell decide its particular identity? According to Caltech biologists, in the case of T cells—immune system cells that help destroy invading pathogens—the answer is when the cells begin expressing a particular gene called Bcl11b.

06/03/2010 18:00:00
Kathy Svitil

Biologists at Caltech have pinpointed molecular changes that helped allow the global spread of resistance to the antiviral medication Tamiflu (oseltamivir) among strains of the seasonal H1N1 flu virus.

05/12/2010 17:00:00
Kathy Svitil

A team of scientists from Columbia University, Arizona State University, the University of Michigan, and Caltech have programmed an autonomous molecular "robot" made out of DNA to start, move, turn, and stop while following a DNA track.

The development could ultimately lead to molecular systems that might one day be used for medical therapeutic devices and molecular-scale reconfigurable robots—robots made of many simple units that can reposition or even rebuild themselves to accomplish different tasks.

04/23/2010 07:00:00
Kathy Svitil

We are not alone—even in our own bodies. The human gut is home to 100 trillion bacteria, which have co-evolved along with our digestive and immune systems. Most people view bacteria as harmful pathogens causing infections and disease. But some microbes, taking a different evolutionary path, have established beneficial relationships with their hosts. Still others may be perched somewhere in between, according to research by Caltech biologists that offers new insight into the causes of inflammatory bowel disease and colon cancer.

04/21/2010 07:00:00
Kathy Svitil

Taking inspiration from a popular executive toy ("Newton's cradle"), researchers at Caltech have built a device—called a nonlinear acoustic lens—that produces highly focused, high-amplitude acoustic signals dubbed "sound bullets." The acoustic lens and its sound bullets (which can exist in fluids—like air and water—as well as in solids) have the potential to revolutionize applications from medical imaging and therapy to the nondestructive evaluation of materials and engineering systems.

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