Zcube Srl, a research venture of the Italian pharmaceutical company Zambon, and Caltech have signed an exclusive research and option agreement to develop and commercialize skin patches that contain embedded carbon nanotubes for delivering drugs.
Each time a virus invades a healthy individual, antibodies created by the body fight to fend off the intruders. For HIV, the antibodies are very specific and are generated too slowly to combat the rapidly changing virus. However, scientists have found that some HIV-positive people develop highly potent antibodies that can neutralize different subtypes of the virus. Now, a study involving Caltech researchers points to the possibility of using these neutralizing antibodies in the development of a vaccine.
Figuring a virus's host is can be difficult, especially when you're talking about bacteriophages, a group of bacteria-infecting viruses. The problem lies in identifying which bacteriophages are infecting which bacteria, without having to culture either the viruses or their hosts in the lab. Now, a Caltech-led team has created a technique that can "physically link single bacterial cells harvested from a natural environment with a viral marker genes," the scientists report in the July 1 issue of the journal Science.
As part of a program to foster innovative biomedical research projects, an anonymous donor has pledged $3 million each to Caltech and City of Hope to strengthen scientific collaborations between the two leading research institutions.
There's a wealth of health information hiding in the human immune system. Accessing it, however, can be very challenging, as the many and complex roles that the immune system plays can mask the critical information that is relevant to addressing specific health issues. Now, research led by scientists from the California Institute of Technology (Caltech) has shown that a new generation of microchips developed by the team can quickly and inexpensively assess immune function.
A team of researchers from the University of California, Los Angeles (UCLA), Caltech, and the University of Louisville have used a stimulating electrode array to assist a paralyzed man to stand, step on a treadmill with assistance, and, over time, to regain voluntary movements of his limbs. The electrical signals provided by the array, the researchers have found, stimulate the spinal cord's own neural network so that it can use the sensory input derived from the legs to direct muscle and joint movements.
Where does violence live in the brain? And where, precisely, does it lay down its biological roots? With the help of a new genetic tool that uses light to turn nerve cells on and off, a team led by researchers at the California Institute of Technology (Caltech) has tracked down the specific location of the neurons that elicit attack behaviors in mice, and defined the relationship of those cells to the brain circuits that play a key role in mating behaviors.
Two scientists from Caltech have been recognized by the National Institutes of Health for their innovative and high-impact biomedical research programs. Michael Roukes, professor of physics, applied physics, and bioengineering, and co-director of the Kavli Nanoscience Institute, and Pamela Bjorkman, Caltech's Max Delbrück Professor of Biology and a Howard Hughes Medical Institute investigator, now join the 81 Pioneers who have been selected since the program's inception in 2004.
One key to fighting diseases such as leukemia and anemia is gaining an understanding of the genes and molecules that control the function of hematopoietic—or blood—stem cells, which provide the body with a constant supply of red and white blood cells and platelets. Biologists at Caltech have taken a large step toward that end, with the discovery of a novel group of molecules that are found in high concentrations within hematopoietic stem cells and appear to regulate their production.