Swaminathan Krishnan’s group is developing end-to-end simulations that holistically simulate the how earthquake begin and progress and how buildings respond to shaking, using high-performance computing. Krishnan collects the synthetic wave data from Shakemovie simulations that run on the Seismo Lab's Beowulf (massively parallel) computer cluster, and applies them to structural models of buildings in his Virtual Shaker software. These simulations model fault rupture, generation and propagation of seismic waves to a site or sites of interest, shaking of the topsoil layer, and the structural response including soil-structure interaction. They estimate losses due to damage and the opportunity cost of interruptions in structure usage.