Thursday, October 11, 2018
4:00 pm

Distinguished Medical Engineering Seminar

Linda L. Demer, M.D., Ph.D., UCLA Department of Medicine, UCLA

Research Interests: It has long been known that bone tissue and even marrow can form in human arteries, usually near cholesterol deposits. This process has been attributed to passive crystal precipitation in dying cells. The Cardiovascular Biomineralization Research Group, directed by Dr. Linda Demer, has shown that the process is both regulated and related to embryonic bone formation. They developed the first tissue culture model of vascular calcification, isolated and cloned the cells responsible for producing calcium mineral, and identified the regulatory molecules controlling the process by which the cells differentiate into bone cells. Based on comparisons to bone cells, they are providing evidence that high cholesterol may contribute not only to atherosclerotic calcification, but also to osteoporosis.

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