Thursday, May 23, 2013
Spalding Laboratory 106 (Hartley Memorial Seminar Room) – Eudora Hull Spalding Laboratory of Engineering
Chemical Engineering Seminar
Folding under pressure: mechanical forces in development of native and engineered tissues
Celeste Nelson, Assistant Professor, Chemical and Biological Engineering, Princeton University
The morphogenetic patterning that generates three-dimensional (3D) tissues requires dynamic concerted rearrangements of individual cells with respect to each other. We have developed microfabrication- and lithographic tissue engineering-based approaches to investigate the mechanical forces and downstream signaling responsible for generating the airways of the lung and the milk ducts of the mammary gland. I will discuss how we combine these experimental techniques with computational models to uncover the physical forces that drive tissue development.